RecruitingNCT06774014

Heart Failure in Patients With Diabetes: Cells, Crosstalk and Consequences


Sponsor

University of Leeds

Enrollment

600 participants

Start Date

Feb 26, 2025

Study Type

OBSERVATIONAL

Conditions

Summary

This will be an observational study to explore differences in pathophysiology between groups of people with and without heart failure (HF) (reduced and preserved ejection fraction) and with and without diabetes mellitus (DM) with a particular focus on cross-talk (fat, muscle, vascular tissue and the heart). The investigators will invite 600 people to partcipate (100 with HFrEF+DM, 100 with HFpEF+DM, 100 with HFpEF-DM, 100 with HFrEF-DM, 100 with DM, 100 without either HR or DM). Special heart scans, exercise testing, blood testing, testing of the automatic nervous system will be performed and in some, samples of fat and muscle and endothelial cells will be collected. These data will be used to create a cohort of well phenotyped patients with a variety of comprehensively collected clinical information, a cell atlas, and a comprehensive assessment of metabolomics, proeomics and cross-talk in between tissues, allowing comparisons between each group.


Eligibility

Min Age: 18 Years

Plain Language Summary

Simplified for easier understanding

This study is investigating how diabetes affects the heart at a cellular level, particularly in people who develop heart failure. Researchers will collect blood samples and study cell communication and tissue changes to better understand this connection. **You may be eligible if...** - You are over 18 years old - You are mentally able to understand and follow study instructions - You are willing to provide written consent **You may NOT be eligible if...** - You have severe anemia (very low hemoglobin) - You have an active serious infection (like pneumonia) - You are in acute heart failure caused by sepsis (severe infection in the bloodstream) - You are experiencing active chest pain or heart attack symptoms - You have severe liver failure, kidney failure, or very severe lung disease - You are pregnant or breastfeeding - You are institutionalized or court-ordered into care - You are currently taking part in another drug trial Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Locations(1)

Leeds Teaching Hospitals NHS Trust

Leeds, West Yorkshire, United Kingdom

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NCT06774014


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