RecruitingNCT06774794

Precision Medicine in the Management of Heart Transplant Recipients

Precision Medicine in the Management of the Heart Transplant Patient: Advanced Molecular and Imaging Approaches


Sponsor

IRCCS Azienda Ospedaliero-Universitaria di Bologna

Enrollment

200 participants

Start Date

Sep 4, 2023

Study Type

OBSERVATIONAL

Conditions

Summary

The goal of this clinical trial is to demonstrate that a multiparametric approach, based on the integration of biomolecular, histological, imaging, and clinical information, along with the use of machine learning methods, can identify among heart transplant patients those at higher risk of rejection, infectious events, and chronic graft dysfunction. Patients have been and will be treated according to clinical practice, in accordance with the physician's judgment and the information provided in the Technical Data Sheet of each individual product used in concomitant therapies, if administered according to clinical practice. The diagnostic-therapeutic pathway of the patients will not be in any way influenced by the results of tissue tests performed for the purposes of the study


Eligibility

Min Age: 18 Years

Inclusion Criteria4

  • Age ≥ 18 years
  • Have received an orthotopic heart transplant
  • Clinical indication for performing a myocardial biopsy (either as part of standard monitoring or for suspected rejection)
  • Obtaining informed consent

Exclusion Criteria1

  • Severe complications in the post-operative phase that may limit the patient's short-term survival.

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Locations(1)

Luciano

Bologna, Italy

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NCT06774794


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