Familial Intrahepatic Cholestasis-related Genes Associated with Disease Susceptibility in Hepato-biliary Cancers

This study is investigating whether inherited gene changes related to a rare liver condition called familial intrahepatic cholestasis may increase the risk of liver and bile duct cancers in patients who have no obvious underlying liver disease. Researchers will analyze genetic samples from patients who had these cancers removed surgically. **You may be eligible if...** - You have been diagnosed with liver or biliary tract cancer (hepatocellular carcinoma, cholangiocarcinoma, or mixed type) without a clear known cause of underlying liver disease - You had your tumor surgically removed or received a liver transplant - You have a chronic liver condition characterized by long-term elevated liver enzymes or itching with high bile acid levels - You are able to provide written informed consent **You may NOT be eligible if...** - Your liver disease is explained by another known cause (such as hepatitis B/C, alcohol, fatty liver) - You are not eligible for or did not undergo surgical treatment Talk to your doctor to see if this trial is right for you.