RecruitingPhase 1NCT05045482

Hepatic Impairment With Cirrhosis Due to Cholestatic Liver Disease

A Phase 1, Open-Label Extension Groups Study in Subjects Having Hepatic Impairment With Cirrhosis Due to Cholestatic Liver Disease


Sponsor

Zydus Therapeutics Inc.

Enrollment

30 participants

Start Date

Oct 21, 2021

Study Type

INTERVENTIONAL

Conditions

Summary

A Phase 1, Open-label Extension Groups Study in Subjects having Hepatic Impairment with Cirrhosis due to Cholestatic Liver Disease


Eligibility

Min Age: 18 YearsMax Age: 80 Years

Plain Language Summary

Simplified for easier understanding

This clinical trial is studying a drug called Saroglitazar Magnesium 1 mg and a drug called Saroglitazar Magnesium 2 mg for people with cholestatic liver disease, cirrhosis, and other related conditions. The study is currently recruiting participants at 1 location. People eligible for this study include aged 18 Years to 80 Years.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

DRUGSaroglitazar Magnesium 1 mg

Group-8: Total of 18 subjects will be enrolled in the Group-8. Group 8A (n=6, consist of mild hepatic impairment subjects); Group 8B (n=6, consist of moderate hepatic impairment), Group 8C (n=3, consist of severe hepatic impairment and Group 8D (n=3, consist of control subjects with normal hepatic functions).

DRUGSaroglitazar Magnesium 2 mg

Group-9: Total of 12 subjects will be enrolled in the Group-9. Group 9A (n=3, consist of mild hepatic impairment subjects); Group 9B (n=3, consist of moderate hepatic impairment), Group 9C (n=3, consist of severe hepatic impairment and Group 9D (n=3, consist of control subjects with normal hepatic functions).


Locations(1)

Zydus US002

Indianapolis, Indiana, United States

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NCT05045482


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