MR Elastography for Assessing Liver Fibrosis in Chronic Hepatitis B
Retrospective and Prospective Multi-center Clinical Study of Magnetic Resonance Elastography in Evaluating Hepatic Fibrosis in Chronic Viral Hepatitis B
Shengjing Hospital
600 participants
Jan 1, 2025
OBSERVATIONAL
Conditions
Summary
How to construct a non-invasive, accurate, and convenient method to evaluate the severity of liver fibrosis (LF) is an important general problem in the management of patients with chronic hepatitis B (CHB). We plan to investigate the ability of magnetic resonance elastography (MRE) to grade fibrosis in chronic hepatitis B and apply to clinical longitudinal follow-up.
Eligibility
Inclusion Criteria6
- Age ≥ 18 years old
- Confirmed CHB (laboratory, imaging and clinical tests)
- MRE within 6 months before and after liver biopsy
- Treatment-naïve
- Child-Pugh Grade A (\<7 points)
- Written informed consent in prospective follow-up cohort
Exclusion Criteria6
- Patients with liver malignant tumor
- Chronic hepatitis due to other causes (such as alcoholic hepatitis)
- CHB combined with hepatitis C, hepatitis D, or HIV
- Patients with biliary tract diseases
- Contraindications of MRE examination, MRE failure
- Poor pathological effect
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Interventions
All imaging studies were performed by using a 1.5T/3.0-T MRI system
Liver biopsy are performed by well-trained pathologists in accordance with standard operating procedures.
Locations(1)
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NCT06779058