Chronic Hepatitis B Clinical Trials

37 recruiting

Chronic Hepatitis B Trials at a Glance

43 actively recruiting trials for chronic hepatitis b are listed on ClinicalTrialsFinder across 6 cities in 26 countries. The largest study group is Phase 2 with 13 trials, with the heaviest enrollment activity in Beijing, Baltimore, and Seoul. Lead sponsors running chronic hepatitis b studies include Beijing Continent Pharmaceutical Co, Ltd., Aligos Therapeutics, and Beijing Friendship Hospital.

Browse chronic hepatitis b trials by phase

Treatments under study

About Chronic Hepatitis B Clinical Trials

Looking for clinical trials for Chronic Hepatitis B? There are currently 37 studies actively recruiting participants. Clinical trials offer access to new treatments before they are widely available, and every approved therapy in use today was first tested through a clinical trial.

Below you can browse trials, sign up for alerts when new Chronic Hepatitis B trials open, and view eligibility criteria for each study. Each listing includes the study phase, locations, and enrollment details.

Frequently Asked Questions

Common questions about Chronic Hepatitis B clinical trials

A clinical trial is a carefully designed research study that tests new medical treatments, drugs, devices, or approaches in human volunteers. Every approved medication and treatment available today was proven safe and effective through clinical trials.

All clinical trials are reviewed and approved by Institutional Review Boards (IRBs) — independent committees that evaluate patient safety. Trials follow strict protocols, and your health is monitored closely throughout. You can withdraw at any time.

Not necessarily. Many trials compare the new treatment against the current standard of care, meaning all participants receive active treatment. When placebos are used, they are typically combined with standard treatment, not given alone. The trial description will always specify the design.

Under the Affordable Care Act, most private insurers are required to cover routine patient care costs during a clinical trial. The sponsor typically covers the investigational treatment itself. Medicare also covers routine costs for qualifying trials.

Yes. Participation is completely voluntary. You can withdraw at any time, for any reason, without it affecting your access to standard medical care.

Each trial has specific eligibility criteria — including age, diagnosis, disease stage, prior treatments, and general health. Browse the trials listed above and check their eligibility sections. You can also contact the trial site directly to discuss your situation.

Showing 120 of 43 trials

Recruiting
Phase 2

A Study Evaluating the Efficacy and Safety of ALG-000184 Compared With Tenofovir Disoproxil Fumarate in Untreated HBeAg-Positive and HBeAg- Negative Adult Subjects With Chronic Hepatitis B (B-SUPREME)

Chronic Hepatitis B Infection
Aligos Therapeutics200 enrolled58 locationsNCT06963710
Recruiting
Phase 2

A Study of Hydronidone Capsules in Patients With Chronic Hepatitis B Virus-Related Liver Fibrosis

Chronic Hepatitis B-related Liver Fibrosis
Beijing Continent Pharmaceutical Co, Ltd.150 enrolled1 locationNCT07417553
Recruiting
Phase 2

Study of Tenofovir Alafenamide (TAF) in Children and Teen Participants With Chronic Hepatitis B Virus Infection

Chronic Hepatitis B
Gilead Sciences150 enrolled62 locationsNCT02932150
Recruiting

Hospital-Based Management of Patients With Chronic Hepatitis B Virus Infection

Chronic Hepatitis B
Third Affiliated Hospital, Sun Yat-Sen University16,300 enrolled3 locationsNCT06966908
Recruiting
Phase 1

A Trial to Evaluate the Efficacy and Safety of WGc0201 in Patients With Chronic Hepatitis B Virus Infection

Chronic Hepatitis B Virus (Hbv)
Jiyan Liu9 enrolled1 locationNCT07051187
Recruiting
Phase 2

A Study to Evaluate the Safety of Hydronidone Capsules in Patients With Liver Fibrosis

Chronic Hepatitis B With Hepatic Fibrosis
Beijing Continent Pharmaceutical Co, Ltd.200 enrolled1 locationNCT07364448
Recruiting
Phase 3

A Clinical Trial Evaluating the Safety of Hydronidone Capsules in Patients With Hepatic Fibrosis and Liver Cirrhosis

Chronic Hepatitis B With Hepatic Fibrosis
Beijing Continent Pharmaceutical Co, Ltd.300 enrolled1 locationNCT07343778
Recruiting
Phase 2

VIR-2218 and Peginterferon Alfa-2a for Chronic Hepatitis B

Chronic Hepatitis B
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)50 enrolled1 locationNCT06092333
Recruiting
Phase 4

SGLT2i to Prevent of Liver Complications in Patients With CHB and Diabetes Mellitus

Chronic Hepatitis B
Chinese University of Hong Kong412 enrolled1 locationNCT06364930
Recruiting
Phase 1

A Study on IB-001 Dose Response and Tolerability in Healthy Adults and Those With Chronic Hepatitis B

Chronic Hepatitis B Virus Infection
IntegerBio90 enrolled1 locationNCT07389044
Recruiting

MR Elastography for Assessing Liver Fibrosis in Chronic Hepatitis B

Liver FibrosisChronic Hepatitis B
Shengjing Hospital600 enrolled1 locationNCT06779058
Recruiting
Phase 1

Single Dose Study to Evaluate the Pharmacokinetics, Safety and Tolerability of Pevifoscorvir Sodium (ALG-000184) in Participants With Renal Impairment and in Healthy Participants With Normal Renal Function

Chronic Hepatitis B Infection
Aligos Therapeutics30 enrolled2 locationsNCT07342881
Recruiting
Phase 2

A Study to Evaluate the Antiviral Activity and Immune Response of AHB-137 Injection in Participants With Chronic Hepatitis B (CHB)

Chronic Hepatitis B
Ausper Biopharma Co., Ltd.30 enrolled1 locationNCT06993480
Recruiting
Phase 3

A Small Sample Prospective Clinical Study of Azvudine Tablets to Promote Clinical Cure in Patients With Chronic Hepatitis B

Chronic Hepatitis BAzvudine
Zhigang Ren120 enrolled1 locationNCT07307586
Recruiting
Phase 1

SA1211 Injection Phase 1 Study

Chronic Hepatitis B
Suzhou Siran Biotechnology Co.,Ltd.80 enrolled1 locationNCT07275918
Recruiting

Combined Use of Bacteroides Fragilis and BCAAs on HBsAg Clearance

Chronic Hepatitis B
First Affiliated Hospital of Fujian Medical University40 enrolled1 locationNCT07257562
Recruiting
Phase 2

A Multicenter, Randomized, Open, Parallel-designed Study to Evaluate the Efficacy and Safety of HRS-5635 Injection Alone or in Combination With Other Agents in Patients Treated for Chronic Hepatitis B

Chronic Hepatitis B
Fujian Shengdi Pharmaceutical Co., Ltd.369 enrolled1 locationNCT06425341
Recruiting
Phase 1

TLR-9 Adjuvanted Vaccination for Chronic Hepatitis B

Hepatitis BChronic Hepatitis B
University of Maryland, Baltimore10 enrolled1 locationNCT04843852
Recruiting
Not Applicable

Gene Discovery in CHB Patients to Identify Unknown Pathways That Lead to B and NK Cell Deregulation

Chronic Hepatitis B Virus
University Hospital, Limoges140 enrolled3 locationsNCT06853886
Recruiting
Phase 2

Intrahepatic and Peripheral Responses to Imdusiran (AB-729) in Chronic Hepatitis B

Chronic Hepatitis B
University of Maryland, Baltimore10 enrolled1 locationNCT06154278