RecruitingNCT06780917

Validating the On-line Creyos Cognitive Assessment Platform in Older Adults With Major Depressive Disorder or Mild Cognitive Impairment


Sponsor

Centre for Addiction and Mental Health

Enrollment

150 participants

Start Date

Jan 13, 2025

Study Type

OBSERVATIONAL

Conditions

Summary

The goal of this observational study is to validate the Creyos online cognitive assessment platform in individuals with mild cognitive impairment, or remitted major depressive disorder. The main objectives of this research are: 1. To confirm the feasibility of administering the Creyos cognitive battery to older adults with Mild Cognitive Impairment MCI) or Major Depressive Disorder in remission (rMDD). 2. To determine whether the Creyos battery can detect changes in cognition that are predictive of changes on paper-and-pencil neuropsychological testing ("gold standard") over up to five years. Participants will complete both in-person neuropsychological testing yearly as well as the Creyos online battery quarterly for up to 5 years, to allow us to compare performance on these two batteries over time.


Eligibility

Min Age: 60 Years

Plain Language Summary

Simplified for easier understanding

This study is testing whether an online computer-based cognitive (thinking and memory) test called Creyos can accurately measure mental performance in older adults with mild cognitive impairment (MCI) or a history of depression. The goal is to validate this tool as a convenient, at-home alternative to in-person testing. **You may be eligible if...** - You are 60 or older (65+ for the depression group) - You can read and communicate in English - You have a diagnosis of mild cognitive impairment (MCI) OR a history of at least one major depressive episode - You have a regular contact person (friend or family) available as a study partner **You may NOT be eligible if...** - You have a lifetime diagnosis of schizophrenia, bipolar disorder, or OCD - You have a substance use disorder in the past 12 months - You are at high risk for suicide - You have significant neurological conditions (e.g., stroke, seizure disorder) - You currently have active depressive symptoms (MADRS score of 10 or above) Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Locations(3)

St. Michael's Hospital

Toronto, Ontario, Canada

University Health Network

Toronto, Ontario, Canada

Centre for Addiction and Mental Health

Toronto, Ontario, Canada

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NCT06780917


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