Mild Cognitive Impairment (MCI) Clinical Trials

22 recruiting

Frequently Asked Questions

Common questions about Mild Cognitive Impairment (MCI) clinical trials

A clinical trial is a carefully designed research study that tests new medical treatments, drugs, devices, or approaches in human volunteers. Every approved medication and treatment available today was proven safe and effective through clinical trials.

All clinical trials are reviewed and approved by Institutional Review Boards (IRBs) — independent committees that evaluate patient safety. Trials follow strict protocols, and your health is monitored closely throughout. You can withdraw at any time.

Not necessarily. Many trials compare the new treatment against the current standard of care, meaning all participants receive active treatment. When placebos are used, they are typically combined with standard treatment, not given alone. The trial description will always specify the design.

Under the Affordable Care Act, most private insurers are required to cover routine patient care costs during a clinical trial. The sponsor typically covers the investigational treatment itself. Medicare also covers routine costs for qualifying trials.

Yes. Participation is completely voluntary. You can withdraw at any time, for any reason, without it affecting your access to standard medical care.

Each trial has specific eligibility criteria — including age, diagnosis, disease stage, prior treatments, and general health. Browse the trials listed above and check their eligibility sections. You can also contact the trial site directly to discuss your situation.

Showing 120 of 28 trials

Recruiting

Validating the On-line Creyos Cognitive Assessment Platform in Older Adults With Major Depressive Disorder or Mild Cognitive Impairment

Mild Cognitive Impairment (MCI)Major Depressive Disorder, RemittedHealthy Controls Group - Age and Sex-matched
Centre for Addiction and Mental Health150 enrolled3 locationsNCT06780917
Recruiting
Not Applicable

Effect of Striatal Temporal Interference Stimulation on Language Processing in Neurodegenerative Diseases

Mild Cognitive Impairment (MCI) AmnesticLewy Body Disease With Mild Cognitive ImpairmentParkinson's Disease With Mild Cognitive Impairment
Masaryk University70 enrolled1 locationNCT07449117
Recruiting
Not Applicable

Study to Investigate Vagus Nerve Stimulation to Augment Executive Function in Healthy and Cognitively Impaired Populations

Mild Cognitive Impairment (MCI)Parkinsons Disease (PD)Healthy Adult
University of Colorado, Denver80 enrolled1 locationNCT07424365
Recruiting
Phase 3

Evaluate the Use of [18F]-APN-1607 PET in Subjects With AD-related Cognitive Impairment and Subjects With Normal Cognitive Function

Subjects With Mild Cognitive Impairment (MCI) of AD, Alzheimer's Disease (AD) Dementia
JYAMS PET Research & Development Limited316 enrolled2 locationsNCT07422857
Recruiting
Not Applicable

Validation of a Digital Intervention to Rehabilitate Cognitive Resources

Mild Cognitive Impairment (MCI)Dementia Alzheimer TypeSubjective Memory Complaint
Fondazione Don Carlo Gnocchi Onlus102 enrolled1 locationNCT07064226
Recruiting

Comprehensive Assessment of Neurodegeneration and Dementia

DementiaMild Cognitive Impairment (MCI)Subjective Cognitive Impairment+7 more
McGill University1,573 enrolled19 locationsNCT03402919
Recruiting
Not Applicable

Positive Psychology for Early Cognitive Decline: Effects on Cognitive and Brain Function

Mild Cognitive Impairment (MCI)Alzheimer Dementia (AD)Subjective Cognitive Decline (SCD)
Aristotle University Of Thessaloniki128 enrolled1 locationNCT07289061
Recruiting
Not Applicable

Early Stage of Alzheimer's and Parkinson's Diseases, HearIng Relevance (SAPHIR)

Healthy ParticipantsMild Cognitive Impairment (MCI) AmnesticParkinson Disease (PD)
Cilcare SAS309 enrolled4 locationsNCT07083089
Recruiting
Not Applicable

Infrared Light for Memory Loss in Mild Cognitive Impairment (MCI)

Mild Cognitive Impairment (MCI) Due to Alzheimer's Disease
Unity Health Toronto60 enrolled1 locationNCT06618807
Recruiting
Phase 1

Safety Of Nrtis for Alzheimer's Therapeutic Advancement in Singapore Study

Mild Cognitive Impairment (MCI)Alzheimer Dementia (AD)
National University Hospital, Singapore48 enrolled1 locationNCT07210528
Recruiting
Not Applicable

TACS to Engage Theta-Gamma Coupling and Enhance Working Memory in Patients With MCI (tACS-MCI)

Mild Cognitive Impairment (MCI)
Centre for Addiction and Mental Health20 enrolled1 locationNCT06783283
Recruiting

A Study To Assess The Feasibility Of Indivi Mobile Application In Monitoring Cognitive Performance In Aging Population

Mild Cognitive Impairment (MCI)Mild Alzheimer Disease
Indivi AG55 enrolled1 locationNCT07174869
Recruiting

Prospective Cohort Study of Patients With Early Alzheimer's Disease Treated With Lecanemab

Alzheimer DiseaseMild Cognitive Impairment (MCI)
Second Affiliated Hospital, School of Medicine, Zhejiang University120 enrolled1 locationNCT06741553
Recruiting
Not Applicable

Impact of a Multimodal Lifestyle Intervention on Dementia Risk Factors and Attitude Related to Dementia Risk: A Logistical Pilot Study

Cognitive ImpairmentMild Cognitive Impairment (MCI)Alzheimer Disease (AD)+1 more
HudsonAlpha Institute for Biotechnology200 enrolled1 locationNCT07146412
Recruiting
Phase 2

Study to Evaluate the Efficacy and Safety of KDS2010 in Patients With Alzheimer's Disease With Mild Cognitive Impairment and Mild Dementia Due to Alzheimer's Disease

Mild Cognitive Impairment (MCI)Mild DementiaAlzheimer's Disease
NeuroBiogen Co., Ltd114 enrolled8 locationsNCT07027072
Recruiting
Not Applicable

Remote Sensing for ADRD-Specific Activities Identification in Older Adults

Mild Cognitive Impairment (MCI)Alzheimer Disease and Related Dementias (ADRD)
University of Missouri-Columbia16 enrolled1 locationNCT07120347
Recruiting

Saliva and Extracellular Vesicles for Neurodegenerative Diseases

Alzheimer DiseaseParkinson DiseaseMild Cognitive Impairment (MCI)+3 more
Fondazione Don Carlo Gnocchi Onlus242 enrolled5 locationsNCT06869135
Recruiting
Not Applicable

Early-Stage Partner in Care Living Alone Plus

DementiaAlzheimer DiseaseMild Cognitive Impairment (MCI)
Arizona State University70 enrolled1 locationNCT06962111
Recruiting
Not Applicable

Time Restricted Eating in Alzheimer's Disease

Mild Cognitive Impairment (MCI)
St. Joseph's Hospital and Medical Center, Phoenix30 enrolled2 locationsNCT06429124
Recruiting
Early Phase 1

Cannabidiol Solution for the Treatment of Behavioral Symptoms in Older Adults With Mild Cognitive Impairment or Alzheimer's Dementia

AnxietyAlzheimer DiseaseMild Cognitive Impairment (MCI) Due to Alzheimer's Disease+1 more
Mclean Hospital12 enrolled1 locationNCT04075435