Mild Cognitive Impairment (MCI) Clinical Trials

55 recruiting

Mild Cognitive Impairment (MCI) Trials at a Glance

57 actively recruiting trials for mild cognitive impairment (mci) are listed on ClinicalTrialsFinder across 6 cities in 14 countries. The largest study group is Not Applicable with 36 trials, with the heaviest enrollment activity in Toronto, Boston, and Phoenix. Lead sponsors running mild cognitive impairment (mci) studies include Casa di Cura IGEA, Centre for Addiction and Mental Health, and Columbia University.

Browse mild cognitive impairment (mci) trials by phase

Treatments under study

About Mild Cognitive Impairment (MCI) Clinical Trials

Looking for clinical trials for Mild Cognitive Impairment (MCI)? There are currently 55 studies actively recruiting participants. Clinical trials offer access to new treatments before they are widely available, and every approved therapy in use today was first tested through a clinical trial.

Below you can browse trials, sign up for alerts when new Mild Cognitive Impairment (MCI) trials open, and view eligibility criteria for each study. Each listing includes the study phase, locations, and enrollment details.

Frequently Asked Questions

Common questions about Mild Cognitive Impairment (MCI) clinical trials

A clinical trial is a carefully designed research study that tests new medical treatments, drugs, devices, or approaches in human volunteers. Every approved medication and treatment available today was proven safe and effective through clinical trials.

All clinical trials are reviewed and approved by Institutional Review Boards (IRBs) — independent committees that evaluate patient safety. Trials follow strict protocols, and your health is monitored closely throughout. You can withdraw at any time.

Not necessarily. Many trials compare the new treatment against the current standard of care, meaning all participants receive active treatment. When placebos are used, they are typically combined with standard treatment, not given alone. The trial description will always specify the design.

Under the Affordable Care Act, most private insurers are required to cover routine patient care costs during a clinical trial. The sponsor typically covers the investigational treatment itself. Medicare also covers routine costs for qualifying trials.

Yes. Participation is completely voluntary. You can withdraw at any time, for any reason, without it affecting your access to standard medical care.

Each trial has specific eligibility criteria — including age, diagnosis, disease stage, prior treatments, and general health. Browse the trials listed above and check their eligibility sections. You can also contact the trial site directly to discuss your situation.

Showing 120 of 57 trials

Recruiting
Not Applicable

Non-invasive Stimulation of Deep Brain Structures to Modulate Working Memory

Mild Cognitive Impairment (MCI)Older Adults (60 - 85 Years Old)
Masaryk University70 enrolled1 locationNCT07560904
Recruiting
Not Applicable

Personalized Digital Training for COGnitive FITness in Mild Cognitive Impairment

Mild Cognitive Impairment (MCI)Subjective Cognitive Decline (SCD)
Giovanna Zamboni100 enrolled2 locationsNCT07286448
Recruiting

Genetic Studies of Early-onset Dementia

Mild Cognitive Impairment (MCI)Alzheimer Dementia (AD)Memory Loss+1 more
Columbia University1,000 enrolled1 locationNCT04906863
Recruiting
Not Applicable

A Multifocal tDCS-EEG Protocol for Improving Symptoms of Mild Cognitive Impairment and Early Dementia

DementiaAlzheimer DiseaseAlzheimer Disease, Early Onset+1 more
University of Campania Luigi Vanvitelli50 enrolled1 locationNCT06668610
Recruiting

InRAD Observational Study

Mild Cognitive Impairment (MCI)Alzheimer's Disease(AD)Subjective Cognitive Decline (SCD)+1 more
Stichting International Registry for Alzheimer's Disease and other Dementias Foundation50,000 enrolled1 locationNCT07213700
Recruiting
Phase 1Phase 2

Biomarker-based Trial of NPC-1 for Alzheimer's Pathology

Alzheimer DiseaseMild Cognitive Impairment (MCI)Subjective Cognitive Complaints (SCCs)
Massachusetts General Hospital40 enrolled1 locationNCT07236190
Recruiting
Not Applicable

Brain Stimulation and Cognitive Training for MCI

Mild Neurocognitive DisorderCognitive DysfunctionMild Cognitive Impairment (MCI)+2 more
Medical University of South Carolina50 enrolled1 locationNCT07526740
Recruiting
Not Applicable

Feasibility Study of 'SuperBrain BOOM' for Mild Cognitive Impairment Patients

Mild Cognitive Impairment (MCI)
Ajou University School of Medicine45 enrolled4 locationsNCT07101380
Recruiting
Not Applicable

TACS to Engage Theta-Gamma Coupling and Enhance Working Memory in Patients With MCI (tACS-MCI)

Mild Cognitive Impairment (MCI)
Centre for Addiction and Mental Health20 enrolled1 locationNCT06783283
Recruiting
Not Applicable

Effects of Real vs. Soundless Acoustic Stimulation During Deep Sleep on Brain Activity, Memory, and Blood Biomarkers in Older Adults (60-85) With Mild Memory Impairment

Cognitive DeclineAlzheimer DiseaseMild Cognitive Impairment (MCI)+2 more
University of Bern60 enrolled1 locationNCT06669546
Recruiting
Not Applicable

Exercises for Rehabilitation of COgnition and Lifestyle Enhancement in Patients With Mild Cognitive Impairment

Mild Cognitive Impairment (MCI)
Casa di Cura IGEA40 enrolled2 locationsNCT07517380
Recruiting

Predicting Pre-dementia

Mild Cognitive Impairment (MCI)Alzheimer Dementia (AD)Alzheimer Disease (AD)+1 more
Prevention Research Consortium Corp.100 enrolled1 locationNCT07516119
Recruiting
Not Applicable

BID WM Digital Intervention in Aging

AgingMild Cognitive Impairment (MCI)Working Memory+1 more
University of California, San Francisco150 enrolled1 locationNCT06918704
Recruiting
Not Applicable

Early-Stage Partner in Care Living Alone Plus

DementiaAlzheimer DiseaseMild Cognitive Impairment (MCI)
Arizona State University70 enrolled1 locationNCT06962111
Recruiting

Global Collaborative Research on Establishing a Korean Cognitive Aging Cohort

Depression - Major Depressive DisorderChronic PainMild Cognitive Impairment (MCI)+1 more
Korea University180 enrolled1 locationNCT07485387
Recruiting

Validating the On-line Creyos Cognitive Assessment Platform in Older Adults With Major Depressive Disorder or Mild Cognitive Impairment

Mild Cognitive Impairment (MCI)Major Depressive Disorder, RemittedHealthy Controls Group - Age and Sex-matched
Centre for Addiction and Mental Health150 enrolled3 locationsNCT06780917
Recruiting
Not Applicable

Effect of Striatal Temporal Interference Stimulation on Language Processing in Neurodegenerative Diseases

Mild Cognitive Impairment (MCI) AmnesticLewy Body Disease With Mild Cognitive ImpairmentParkinson's Disease With Mild Cognitive Impairment
Masaryk University70 enrolled1 locationNCT07449117
Recruiting
Not Applicable

Study to Investigate Vagus Nerve Stimulation to Augment Executive Function in Healthy and Cognitively Impaired Populations

Mild Cognitive Impairment (MCI)Parkinsons Disease (PD)Healthy Adult
University of Colorado, Denver80 enrolled1 locationNCT07424365
Recruiting
Not Applicable

Instant Message-delivered Personalised Acceptance and Commitment Therapy (IMPACT) for Neuropsychiatric Symptoms in Persons With Mild Cognitive Impairment

Mild Cognitive Impairment (MCI)
The University of Hong Kong160 enrolled1 locationNCT07420426
Recruiting
Phase 3

Evaluate the Use of [18F]-APN-1607 PET in Subjects With AD-related Cognitive Impairment and Subjects With Normal Cognitive Function

Subjects With Mild Cognitive Impairment (MCI) of AD, Alzheimer's Disease (AD) Dementia
JYAMS PET Research & Development Limited316 enrolled2 locationsNCT07422857