RecruitingPhase 1NCT06783569

A First-in-Human Escalation and Expansion Study of Patients With Advanced Solid Tumors

A First-in-Human, Open-Label, Dose Escalation and Expansion Study of JR8603 in Patients With Advanced Solid Tumors


Sponsor

JiaRay Group

Enrollment

94 participants

Start Date

Dec 31, 2024

Study Type

INTERVENTIONAL

Conditions

Summary

The goal of this clinical trial is to learn if the investigational drug (JR8603) is safe and effective in treating patients with solid tumors after their initial rounds of treatment with other drugs did not work.


Eligibility

Min Age: 18 Years

Plain Language Summary

Simplified for easier understanding

This is a first-in-human study testing a new experimental drug in people with advanced solid tumors that have progressed on or become resistant to all available standard treatments. The study aims to determine a safe dose and observe early signs of effectiveness. **You may be eligible if...** - You are 18 or older - You have a locally advanced or metastatic solid tumor with no remaining standard treatment options - You have measurable disease on imaging - Your life expectancy is at least 3 months - Your blood counts, liver, and kidney function are within acceptable limits **You may NOT be eligible if...** - Your organ function is inadequate - You are pregnant or breastfeeding - You have active serious infections or uncontrolled medical conditions - Your cancer has not progressed on all standard therapies Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

DRUGJR8603

IV infusion on Days 1, 8, and 15 of continuous 28-day cycles


Locations(2)

Harbin Medical University Cancer Hospital

Harbin, Heiljiang Province, China

Liaoning Cancer Hospital

Shenyang, Liaoning, China

View Full Details on ClinicalTrials.gov

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NCT06783569


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