Mechanistic and Clinical Outcomes of a Surgical Innovation Aimed at Minimizing GERD Associated With VSG (INNOVATE-VSG)

This two-site randomized trial tests whether a modified version of sleeve gastrectomy — a popular weight-loss surgery — can reduce acid reflux (GERD) compared to the standard surgical technique, which is known to worsen reflux in many patients. The modified procedure aims to preserve or recreate a natural valve at the lower end of the esophagus that prevents stomach acid from flowing upward. Adults aged 18–65 with a BMI of 35–55 kg/m², confirmed GERD (measured by a pH test), and health insurance covering bariatric surgery who have not had prior weight-loss or anti-reflux surgery may be eligible. Participation involves the assigned surgical procedure followed by measurement tests (pH monitoring, manometry, endoscopy) and quality-of-life questionnaires at 6–9 months and 12 months post-surgery. This summary was generated by AI to help patients understand the study in plain language.