RecruitingPhase 2NCT06786026

QL1706 Plus Chemotherapy +/- Bevacizumab in 1L Treatment of R/mTNBC

QL1706 Plus Nab-paclitaxel +/- Bevacizumab As 1L Treatment in Recurrent or Metastatic Triple-Negative Breast Cancer: a Non-randomized, Multicenter Phase II Study


Sponsor

Fudan University

Enrollment

60 participants

Start Date

Oct 9, 2024

Study Type

INTERVENTIONAL

Conditions

Summary

This study is to evaluate the efficacy and safety of QL1706 plus albumin-bound paclitaxel ± bevacizumab in 1L treatment of r/mTNBC


Eligibility

Sex: FEMALEMin Age: 18 YearsMax Age: 75 Years

Plain Language Summary

Simplified for easier understanding

This study is testing a combination of immunotherapy (QL1706) with chemotherapy, with or without the drug bevacizumab, as a first-line treatment for women with triple-negative breast cancer (TNBC) that has spread or cannot be surgically removed. TNBC is an aggressive form of breast cancer that lacks the hormone and HER2 receptors. **You may be eligible if...** - You are a woman between 18 and 70 years old - You have been diagnosed with triple-negative breast cancer (ER-, PR-, HER2-negative) confirmed by biopsy - Your cancer has spread or come back and you have not had prior systemic treatment for advanced disease - You have at least one measurable tumor site **You may NOT be eligible if...** - Your breast cancer is not triple-negative - You have already received treatment for metastatic or locally advanced disease (except prior adjuvant/neoadjuvant therapy given long enough ago) - You have significant health conditions that prevent participation Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

DRUGbevacizumab

bevacizumab

DRUGQL1706

Bispecific antibody (bsAB) targeting PD-1 and CLTA-4

DRUGNab paclitaxel

albumin-bound paclitaxel


Locations(1)

Fudan University Shanghai Cancer Center

Shanghai, Shanghai Municipality, China

View Full Details on ClinicalTrials.gov

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NCT06786026


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