RecruitingNCT06786169

The Relationship of Psychological Stress With Therapy Efficacy and Prognosis of Gastric Cancer

Cohort Studies of Associations of Psychological Stress With Therapy Efficacy and Prognosis of Gastric Cancer (G-STRESS)

Sponsor

Fudan University

Enrollment

600 participants

Start Date

Sep 5, 2024

Study Type

OBSERVATIONAL

Conditions

Gastric Cancer, Gastroesophageal Junction Cancer

Summary

This is the prospective, observational cohort study (G-Distress) to explore the associations of psychological stress with treatment and prognosis of gastric cancer. The participants including the patients diagnosed with gastric cancer who received surgery, chemotherapy and immune checkpoint inhibitors.

Eligibility

Min Age: 18 YearsMax Age: 80 Years

Plain Language Summary

Simplified for easier understanding

This study is investigating whether psychological stress affects how well treatment works and the long-term outlook for patients with stomach cancer (gastric cancer). Researchers believe stress may influence the immune system and cancer progression. **You may be eligible if...** - You are between 18 and 80 years old - You have been diagnosed with Stage II or III primary gastric (stomach) adenocarcinoma - You had surgery to remove the cancer (R0 gastrectomy with D2 lymph node removal) - You are receiving adjuvant (post-surgery) chemotherapy - Your physical functioning is good (ECOG 0 or 1) **You may NOT be eligible if...** - You have previously had chemotherapy, radiation, immunotherapy, or targeted therapy - You have another active primary cancer - You have serious cardiovascular, respiratory, kidney, or liver disease Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

OTHERpsychological stress status

The assessment of depressive and anxiety symptoms was conducted using Patient Health Questionnaire-9 (PHQ-9) and Generalized Anxiety Disorder Assessment 7 (GAD-7). Patients with a PHQ-9 score ≥ 5 or a GAD-7 score ≥ 5 were categorized as the stressed group.