RecruitingPhase 1Phase 2NCT07115043

A Study to Investigate Safety of AZD6750 in Adult Participants With Select Advanced or Metastatic Solid Tumors

A Phase I/II Open-label Dose Escalation and Expansion Study to Evaluate the Safety, Pharmacokinetics, Pharmacodynamics, and Efficacy of AZD6750, a CD8 Guided IL-2 Agent Alone and in Combination With Other Anti-cancer Agents in Participants With Select Advanced or Metastatic Solid Tumors


Sponsor

AstraZeneca

Enrollment

60 participants

Start Date

Jul 29, 2025

Study Type

INTERVENTIONAL

Conditions

Summary

A Study to Investigate Safety of AZD6750 in Adult Participants With Select Advanced or Metastatic Solid Tumors


Eligibility

Min Age: 18 Years

Plain Language Summary

Simplified for easier understanding

This trial tests an experimental drug called AZD6750 in people with advanced or metastatic solid tumors that have not responded to standard treatments. The drug is designed to help the immune system fight cancer more effectively. **You may be eligible if...** - You are 18 or older and weigh at least 35 kg (77 lbs) - You have confirmed advanced cancer (eligible types include skin cancers, lung cancer, head and neck cancer, gastric cancer, kidney cancer, ovarian cancer, or triple-negative breast cancer) - You have received standard-of-care treatment already - Your heart, liver, bone marrow, and kidneys are functioning adequately **You may NOT be eligible if...** - You have a history of organ or stem cell transplant - You have an active or recent autoimmune or inflammatory disorder - You have severe or uncontrolled heart, lung, or other systemic disease - You are pregnant or breastfeeding Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

Interested in this trial?

Get notified about updates and connect with the research team.

Interventions

DRUGAZD6750

AZD6750- CD8 guided IL-2

DRUGrilvegostomig

Rilvegostomig- PD1-TIGIT bispecific antibody


Locations(11)

Research Site

Grand Rapids, Michigan, United States

Research Site

St Louis, Missouri, United States

Research Site

Pittsburgh, Pennsylvania, United States

Research Site

Houston, Texas, United States

Research Site

San Antonio, Texas, United States

Research Site

Fairfax, Virginia, United States

Research Site

East Melbourne, Australia

Research Site

Chūōku, Japan

Research Site

Kashiwa, Japan

Research Site

Seoul, South Korea

Research Site

Seoul, South Korea

View Full Details on ClinicalTrials.gov

For the most up-to-date information, visit the official listing.

Visit

NCT07115043


Related Trials