RecruitingEarly Phase 1NCT06787066

Sympathetic Vascular Transduction Across the Menopause Transition: Contributing Mechanisms

Sponsor

University of Missouri-Columbia

Enrollment

75 participants

Start Date

Jul 10, 2025

Study Type

INTERVENTIONAL

Conditions

Menopause

Summary

The investigators aim to assess the interactions between the sympathetic nervous system and the vasculature in women across the menopause transition to better understand why aging women have a higher risk of cardiovascular disease.

Eligibility

Sex: FEMALEMin Age: 18 YearsMax Age: 70 Years

Inclusion Criteria3

Assigned female at birth
-70 years of age
Body mass index (BMI) <30 kg/m2

Exclusion Criteria12

Assigned male at birth
Pregnancy, breastfeeding
Body mass index ≥30 kg/m2
Oral hormonal contraception in last 6 months, history of hormone replacement therapy, oophorectomy
Current smoking/nicotine use
Increased risk of bleeding, pro-coagulant disorders, clotting disorders, anticoagulation therapy
Nerve/neurologic disease
Cardiovascular, hepatic, renal, respiratory disease
Blood pressure ≥140/90 mmHg
Diabetes, Polycystic ovarian syndrome
Communication barriers
Prescription medications