RecruitingNCT06791915

Effect of Mechanical Ventilation on Radiofrequency Ablation in Atrial Fibrillation

The Effect of Mechanical Ventilation on Radiofrequency Ablation in The Treatment of Atrial Fibrillation.


Sponsor

Kocaeli City Hospital

Enrollment

50 participants

Start Date

Jan 1, 2025

Study Type

OBSERVATIONAL

Conditions

Summary

Radiofrequency ablation (RFA) for atrial fibrillation (AF) is performed under general anesthesia. The success of the procedure depends on the safe contact of the catheter electrode with the myocardium. Movement of the catheter tip due to respiratory changes can result in inadequate lesion formation and AF recurrence. The success of AF ablation depends on the adequacy of energy delivered to the myocardium and the durability of pulmonary vein isolation (PVI). Poor energy delivery and tissue heating during ablation are a major cause of procedural failure in RFA. To improve the success of the PVI procedure, efforts are underway to optimize catheter stability and contact force. However, catheter force and stability are influenced by respiration-induced thoracic motion, highlighting the importance of controlled breathing for further optimization. Fluoroscopy and ablation times during electroanatomic mapping-guided AF ablations improved with controlled mechanical ventilation. General anesthesia improved catheter contact. Low tidal volume, high respiratory rate (FCV), pressure controlled mechanical ventilation (PCV), volume controlled mechanical ventilation (VCV), pressure controlled volume assured mechanical ventilation (PRVC) can be used in investigators' hospital. The literature offers no definitive proof that one ablation procedure is superior to another.


Eligibility

Min Age: 18 Years

Plain Language Summary

Simplified for easier understanding

This study looks at how the way a patient breathes during general anesthesia (using a ventilator) affects the success of a heart procedure called radiofrequency ablation, which is used to treat an irregular heartbeat known as atrial fibrillation. **You may be eligible if...** - You have been diagnosed with atrial fibrillation (an irregular heartbeat) - You are scheduled to have radiofrequency ablation surgery under general anesthesia - You are 18 or older **You may NOT be eligible if...** - Your ablation procedure will be done under sedation or local anesthesia only (not full general anesthesia) Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

PROCEDURERadiofrequency Ablation with FCV.

Treatment of atrial fibrillation patients with radiofrequency ablation under general anesthesia with Flow Controlled Mechanical Ventilation (FCV).

PROCEDURERadiofrequency Ablation with VCV.

Treatment of atrial fibrillation patients with radiofrequency ablation under general anesthesia with Volume Controlled Mechanical Ventilation (VCV).


Locations(1)

Kocaeli City Hospital

Kocaeli, Turkey (Türkiye)

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NCT06791915


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