RecruitingPhase 4NCT06792422

A Study Investigating Oral Semaglutide in People with Open-Angle Glaucoma

Additive Benefits of Semaglutide for Open-AngLe Glaucoma - an Opportunity for Neuroprotection


Sponsor

Glostrup University Hospital, Copenhagen

Enrollment

126 participants

Start Date

Jan 1, 2025

Study Type

INTERVENTIONAL

Conditions

Summary

The aim of this clinical trial is to investigate whether oral semaglutide can be used to treat open-angle glaucoma. The main question it aims to answer is: Does oral semaglutide safely improve inner retinal function in patients with open-angle glaucoma as measured by the photopic negative response of the electroretinogram. Researchers will compare oral semaglutide to a placebo (a look-alike substance that contains no drug). Participants will: * Take semaglutide or a placebo every day for 6 months. * Visit the clinic 5 times in total for tests and interviews: At baseline (the first day they are included in the study), after 1 month, after 2 months, after 3 months, and after 6 months (the last day they are included in the study).


Eligibility

Min Age: 45 Years

Plain Language Summary

Simplified for easier understanding

This study tests whether oral semaglutide — a medication commonly used for diabetes and weight loss — can also help protect vision in people with a type of glaucoma called open-angle glaucoma. Glaucoma slowly damages the optic nerve and can lead to blindness if untreated. **You may be eligible if...** - You are 45 or older with a diagnosis of primary open-angle glaucoma - You are already on eye pressure-lowering treatment - Your vision in the study eye meets minimum standards - You can speak and read Danish **You may NOT be eligible if...** - You have diabetes or kidney problems - You have had other significant eye conditions or eye surgery in the past 3 months - You are pregnant, breastfeeding, or currently a smoker - You are not using adequate contraception (if applicable) Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

DRUGOral semaglutide

Participants will receive oral semaglutide once daily. 1. Starting dose 3 mg/day for one month (day 1-28) 2. Intermediate dose 7 mg/day for one month (day 29-56) 3. Maintenance dose 14 mg/day (day 57-182)

DRUGPlacebo

Participants will receive an oral placebo once daily. 1. Placebo tablets received on visit 1 (baseline) for one month (day 1-28) 2. Placebo tablets received on visit 2 (month 1) for one month (day 29-56) 3. Placebo tablets received on visit 3 (month 2) for four months (day 57-182)


Locations(1)

Department of Ophthalmology, Rigshospitalet

Glostrup Municipality, Denmark

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NCT06792422


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