Anxiety During Abstinence in AUD
Neural Mechanisms of Anxiety During Early and Protracted Abstinence in Alcohol Use Disorder
Columbia University
60 participants
Sep 15, 2025
INTERVENTIONAL
Conditions
Summary
The goal of this study is to better understand the underlying neurobiological basis of anxiety that emerges during abstinence in patients with alcohol use disorder (AUD). The main questions it aims to answer are: 1. To characterize anxiety itself as well as anxiety related-neurobiological circuitry in early abstinence in AUD 2. To examine how anxiety and anxiety related-neurobiological circuitry change over the course of abstinence in AUD Researchers will recruit both participants with AUD and healthy volunteers. The participants with AUD will be prescribed disulfiram, a medication that helps participants with AUD stay abstinent. Healthy volunteers will not receive antabuse. Patients with AUD will undergo fMRI scanning both after 1 week and 3 months of disulfiram treatment. Healthy volunteers will undergo fMRI once.
Eligibility
Plain Language Summary
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Interventions
Disulfiram will be used in Participants with Alcohol Use Disorder only to facilitate abstinence.
Participants will undergo fMRI scanning. Participants with alcohol use disorder will undergo scanning after 1 week and 3 months of disulfiram maintenance. Healthy volunteer participants will undergo scanning once.
Locations(1)
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NCT06793488