Assessments of Metabolic Responses to Acute Oral Administration of Sucrose, Glucose, and Fructose
Assessments of Metabolic Responses to Acute Oral Administration of Sucrose, Glucose, and Fructose in Healthy Humans
University Hospital, Basel, Switzerland
20 participants
Feb 6, 2025
INTERVENTIONAL
Conditions
Summary
This project aims to compare the acute metabolic effects of the three sweeteners sucrose, glucose, and fructose on GI hormones (GLP-1, PYY, CCK, and ghrelin). Furthermore, glycemic control, erythritol and xylitol concentrations, blood coagulation function , blood lipids, uric acid, high-sensitive C-reactive protein (hsCRP), complete blood count, gastric emptying, appetite-related sensations, and GI symptoms will be investigated.
Eligibility
Inclusion Criteria4
- Healthy, non-diabetic (glycated hemoglobin (HbA1c) \< 5.7%, fasting glucose \< 5.6 mmol/L), and normal weight participants with a body-mass index (BMI) of 19.0-24.9 kg/m2, parameters of complete blood count within normal range
- Age 18-55 years
- Stable body weight (± 5%) for at least three months
- Able to give informed consent as documented by signature
Exclusion Criteria9
- Fructose intolerance
- Any pre-existing diet (e.g., vegetarian diet, vegan diet, sugar free diet, paleo diet, Atkins diet, ketogenic diet) that deviates from normal eating habits
- Regular consumption (\>1/ week) of erythritol or xylitol
- Regular intake of medications, except contraceptives
- Pre-existing impairment of blood coagulation/thrombocyte function (e.g. hereditary, regular intake of anti-coagulant agents (e.g. NSAIDs, heparin, warfarin, etc.))Chronic or clinically relevant acute infections/diseases
- Substance abuse (more than 1 glass wine/beer per day; regular consumption of cannabis, consumption of cocaine, heroin, etc.), regular smoking
- Pregnancy: although no contraindication, pregnancy might influence metabolic state. Women who are pregnant or have the intention to become pregnant during the course of the study are excluded. In female participants a urine pregnancy test is carried out upon screening.
- Shift worker
- Participation in another study with investigational drug within the 30 days preceding and during the present study
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Interventions
33.5g sucrose dissolved in 300mL tap water
33.5g glucose dissolved in 300mL tap water
33.5g fructose dissolved in 300mL tap water
300mL water
Locations(1)
View Full Details on ClinicalTrials.gov
For the most up-to-date information, visit the official listing.
NCT06799715