RecruitingPhase 4NCT05644717

Effect of Erugliflozin On Liver Fat, Liver Fibrosis and Glycemic Control in Type II DM Patients With NASH/NAFLD

Effects of Ertugliflozin on Liver Fat, Liver Fibrosis & Glycemic Control in Subjects With Type 2 Diabetes Mellitus (T2DM) & Non-Alcoholic Fatty Liver Disease /Non-Alcoholic Steatohepatitis


Sponsor

Getz Pharma

Enrollment

164 participants

Start Date

Mar 1, 2023

Study Type

INTERVENTIONAL

Conditions

Summary

Open-label, prospective, single-arm, multicenter study to determine effects of Ertugliflozin on liver fat, liver fibrosis \& glycemic control in subjects with Type 2 Diabetes Mellitus (T2DM) with Non-Alcoholic Fatty Liver Disease (NAFLD)/Non-Alcoholic Steatohepatitis (NASH)


Eligibility

Min Age: 18 YearsMax Age: 65 Years

Plain Language Summary

Simplified for easier understanding

This study is testing whether a diabetes drug called erugliflozin (an SGLT2 inhibitor) can reduce liver fat and liver scarring (fibrosis) in people with Type 2 diabetes who also have fatty liver disease (NASH or NAFLD), while also improving blood sugar control. **You may be eligible if...** - You are between 18 and 65 years old - You have Type 2 diabetes with an HbA1c between 6.5% and 10% - You have a BMI above 23 kg/m² - You have fatty liver disease confirmed by ultrasound - You have not previously used SGLT2 inhibitors or insulin **You may NOT be eligible if...** - You have used SGLT2 inhibitors, GLP-1 medications, or insulin in the past 3 months - You have used pioglitazone in the past 6 months - You have had bariatric (weight loss) surgery or used weight loss medications recently - You have uncontrolled thyroid disease, serious kidney disease, or Type 1 diabetes Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

DRUGErtugliflozin 5 mg, 15mg

Ertugliflozin 5/15mg once daily in addition to standard of care


Locations(1)

North west general hospital

Peshawar, KPK, Pakistan

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NCT05644717


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