RecruitingPhase 2Phase 3NCT06801522

Adrenaline Nasal Pack vs Xylometazoline Nasal Drops During Nasotracheal Intubation

Comparison of the Efficacy of Adrenaline Nasal Pack and Xylometazoline Nasal Drops in Decreasing Nasal Bleeding During Nasotracheal Intubation


Sponsor

Shaheed Mohtarma Benazir Bhutto Institue of Trauma

Enrollment

70 participants

Start Date

Dec 1, 2024

Study Type

INTERVENTIONAL

Conditions

Summary

The goal of this trial is to compare efficacy of xylometazoline nasal drops and adrenaline nasal pack in participants undergoing elective oromaxillofacial surgeries. The main question aim to answer is xylometazoline nasal drops better than adrenaline nasal packing in terms of nasal bleeding during nasotracheal intubation. Researchers are comparing 2 groups of participants. Participants in group Xylometazoline are receiving 0.1% xylometaxoline nasal drops. Participants in group Adrenaline are receiving adrenaline nasal packing.


Eligibility

Min Age: 18 YearsMax Age: 60 Years

Plain Language Summary

Simplified for easier understanding

This study is comparing two medications used to shrink the nasal lining before passing a breathing tube through the nose during surgery — adrenaline-soaked nasal packs versus xylometazoline nasal drops — to see which reduces nosebleeds and discomfort more effectively. **You may be eligible if...** - You are between 18 and 60 years old - You are having planned (elective) jaw or facial surgery that requires nasal intubation (breathing tube through the nose) - You are in generally good health (ASA Class 1 or 2) - You have a normal airway (Mallampati score 1 or 2) **You may NOT be eligible if...** - You have a history of nasal surgery, trauma, polyps, or blockage - You have repeated nosebleeds - You take blood thinners - You have uncontrolled high blood pressure, diabetes, or a history of heart or stroke events - You are pregnant Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

DRUG0.1% xylometazoline nasal drops

Xylometazoline is direct acting, non selective, adrenergic agonist binding with alpha 1\&2 receptors, used for vasoconstriction to decrease nasal bleeding.

DRUGAdrenaline nasal pack

Adrenaline is direct acting, non selective, adrenergic agonist binding with alpha and beta receptors both, used for vasoconstriction to decrease nasal bleeding.


Locations(1)

Shaheed Mohtarma Benazir Bhutto Institute of Trauma

Karachi, Sindh, Pakistan

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NCT06801522


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