RecruitingPhase 1Phase 2NCT06814522

Psilocybin-Assisted Therapy for Physician Well-Being and Burnout

Psilocybin-Assisted Therapy for Physician Well-Being and Burnout: Feasibility, Safety, Clinical Effectiveness and Biomarkers of Response [PAT-B (Psilocybin-Assisted Therapy for Physician Well-Being and Burnout)]

Sponsor

University of California, San Diego

Enrollment

10 participants

Start Date

Jan 13, 2025

Study Type

INTERVENTIONAL

Conditions

Burnout Burnout, Healthcare Workers

Summary

Through an open-label study involving a small group of UCSD physicians experiencing burnout, the investigators will evaluate the feasibility, safety, and preliminary effectiveness of PAT to reduce burnout symptoms.

Eligibility

Min Age: 21 YearsMax Age: 70 Years

Inclusion Criteria6

UCSD faculty physician, aged 21-70. Volunteer faculty are not included
Meets criteria for physician burnout
Experiencing symptoms of burnout for >6 months
Able to complete all required study visits
Not previously diagnosed with a serious mental illness (including schizophrenia, bipolar disorder, and severe depression), or substance use disorder as confirmed in clinical interview
Not currently taking any psychotropic medications or nonpsychotropic medication that may be associated with serotonin syndrome, such as serotonin reuptake inhibitors (SSRI or SNRI), dextromethorphan, linezolid, tramadol, meperidine

Exclusion Criteria12

Previous inpatient psychiatric hospitalization(s)
Previously diagnosed with a psychotic disorder (schizophrenia, schizoaffective disorder, or other psychotic spectrum disorder), bipolar spectrum disorder, personality disorder (borderline personality disorder, antisocial personality disorder, or other severe personality disorders), any severe psychiatric disorder.
Exhibiting elevated suicide risk
First degree family history of psychosis or bipolar disorder
Prior exposure to psilocybin or other psychedelic compounds in the previous 10 years
Currently pregnant, nursing, planning pregnancy, engaging in sexual intercourse without effective contraceptive method in last three months
Those who plan to donate sperm within three months following the study.
Known cardiovascular disease including history of stroke, myocardial infarction, uncontrolled hypertension, valvular heart disease, tachycardia, elongated QT interval, or clinically significant arrythmia.
History of seizure disorder
Use of recreational illicit drugs
Clinically concerning results from vital signs, ECG, physical examination, or laboratory tests during screening
Any other clinically significant illnesses deemed to pose risk for the participant