Efficacy and Safety of Transcranial dIrect Current stiMulation in Multiple System Atrophy-Cerebellar Variant
Efficacy and Safety of Transcranial dIrect Current stiMulation (tDCS) on Cerebellar Symptoms in Multiple System Atrophy-Cerebellar Variant (MSA-C) (STIM-MSA)
University of Salerno
30 participants
Jul 3, 2023
INTERVENTIONAL
Conditions
Summary
This is a double-blind, randomized, sham-controlled clinical trial that aim to verify the safety and the efficacy of anodal transcranial direct current stimulation (tDCS) cerebellar symptoms in Multiple System Atrophy type C (MSA).
Eligibility
Inclusion Criteria2
- Multiple system atrophy cerebellar variant according with the Movemente Disorder Society criteria (Wenning et al 2022)
- Ability to walk either indipendently or with a minimum support
Exclusion Criteria9
- Presence of electrical stimulators (for example, pacemaker, Deep Brain Stimulation, DBS)
- Difficult in understanding Italian language
- Presence of severe sensory deficits (for example, visual or hearing impairments)
- History of drug abuse
- History of severe psychiatric disorders
- History of transient ischemic attacks
- Cortical or sub-cortical vascular lesions
- Seizures or severe heart problems and previous neurosurgical operations
- Pregnancy
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Interventions
tDCS is delivered by a battery-driven constant current stimulator throught a pair of saline soaked surface sponge electrodes. The active electrode (anode) is placed on the scalp over the over the cerebellum area (2 cm under the inion, using a 7 × 5 cm sponge electrode), with the cathode being applied either to the right deltoid muscle (arm 1: cerebellar stimulation) or over the spinal lumbar enlargement (2 cm under T11; arm 2: cerebellar-spinal stimulation) using a sponge electrode of the same size as the anode. Durng real stilumation a costant current of 2mA is applied for 20 minutes.
For the sham condition the electrode placement is the same of active tDCS but the electric current is ramped down 5 seconds after the beginning of the stimulation
Locations(1)
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NCT06821256