RecruitingNCT06890377
Targeted Α-synuclein PET Imaging in the Diagnosis of Multiple System Atrophy
Sponsor
Min Zhao,MD
Enrollment
90 participants
Start Date
Sep 14, 2024
Study Type
OBSERVATIONAL
Conditions
Summary
The aim of this study was to apply the targeted α-synuclein PET study technique to investigate the pathological load and spatial distribution characteristics of α-syn in MSA patients, and to assess its value as a biomarker for diagnostic typing, disease severity, and prognosis in MSA.
Eligibility
Min Age: 35 YearsMax Age: 80 Years
Inclusion Criteria4
- Age\> 35 years old, gender is not limited;
- Clinically confirmed MSA and clinically probable MSA according to the 2022 MDS MSA diagnostic criteria;
- all patients had been ruled out of polyQ disease by genetic testing;
- Voluntarily participate in this study and sign the informed consent form.
Exclusion Criteria4
- pregnancy or breastfeeding;
- contraindications to MRI examination or inability to cooperate in completing neuroimaging examination;
- previous history of other neurological disorders or presence of other organic intracranial lesions on neuroimaging that cannot be interpreted by MSA, such as epilepsy, trauma, tumors, or high-grade cerebral white matter degeneration (Fazekas grade 2 and above);
- History of alcohol or drug abuse
Locations(1)
View Full Details on ClinicalTrials.gov
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NCT06890377