RecruitingPhase 1NCT06822868

A Clinical Study Exploring CT1190B in the Treatment of Patients With Relapsed/Refractory B-cell Non-Hodgkin Lymphoma

A Clinical Study to Investigate the Safety, Efficacy, and Cellular Metabolism of CT1190B CAR-T Cell Therapy, in Patients With Relapsed/Refractory B-Cell Non-Hodgkin Lymphoma


Sponsor

Kai Hu

Enrollment

24 participants

Start Date

Feb 10, 2025

Study Type

INTERVENTIONAL

Conditions

Summary

A Clinical Study to Investigate the Safety, Efficacy, and Cellular Metabolism of CT1190B CAR-T Cell therapy, in Patients with Relapsed/Refractory B-Cell Non-Hodgkin Lymphoma.


Eligibility

Min Age: 18 YearsMax Age: 75 Years

Plain Language Summary

Simplified for easier understanding

This study is testing a new CAR-T cell therapy called CT1190B for people with B-cell non-Hodgkin lymphoma (a type of blood cancer) that has come back or stopped responding to previous treatments. **You may be eligible if...** - You are 18–75 years old - You have been diagnosed with B-cell non-Hodgkin lymphoma - You have already tried at least 2 different treatments that have not worked - You are physically well enough to carry out daily activities (ECOG score 0–1) - You have measurable disease on scans - You are expected to live at least 12 more weeks - You are willing to use effective contraception for 1 year after treatment **You may NOT be eligible if...** - You are pregnant or breastfeeding - You have HIV, active hepatitis B or C, syphilis, or uncontrolled active infection - You have had serious heart problems in the past 6 months - You are currently taking high-dose steroids - You have another active cancer requiring treatment - Side effects from your previous cancer treatment have not fully resolved Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

DRUGCAR T cells

chimeric antigen receptor T cells


Locations(1)

Beijing GoBroad Hospital

Beijing, Beijing Municipality, China

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NCT06822868


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