Anti-hypertensive Therapy and Exercise Treatment to Improve Vascular Health in Patients With Hypertension.
Anti-hypertensive Therapy and Exercise Treatment to Improve Vascular Health in Patients With Hypertension. A Randomized Controlled Trial.
Heinrich-Heine University, Duesseldorf
60 participants
Apr 1, 2025
INTERVENTIONAL
Conditions
Summary
This is a prospective, monocentric, randomized controlled trial to investigate the effect of anti-hypertensive treatment and/or individualized exercise training intervention on blood pressure and vascular health. Furthermore the investigators want to decipher mechanisms, which contribute to vascular health by analyzing changes in metabolism and cell function in relation to vascular reaction.
Eligibility
Inclusion Criteria1
- \- systolic hypertension grade I-II (BP values \>140 mmHg to \<180 mmHg) without anti-hypertensive medication treatment
Exclusion Criteria5
- no written informed consent
- age \<18 years
- isolated diastolic hypertension
- medical contraindications for the exercise treatment (for example orthopedic problems or an abnormal ECG during the cardio respiratory exercise test)
- chronic eye diseases on both eyes (for example macular degeneration or glaucoma) or high intraocular pressure (\>20 mmHg)
Interventions
Patients in the intervention group will receive an individualized exercise training program 3x/week.
The lifestyle recommendation group will receive general recommendations such as salt reduction, higher physical activity levels and stress reduction.
Locations(1)
View Full Details on ClinicalTrials.gov
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NCT06823570