RecruitingNot ApplicableNCT06825078

Performance of Lung MRI Combined to Synthetic CT in the Follow-up of Lung Nodules

Sponsor

University Hospital, Bordeaux

Enrollment

50 participants

Start Date

Feb 12, 2025

Study Type

INTERVENTIONAL

Conditions

Lung Cancer

Summary

Lung cancer screening trials using low-dose chest CT scans have shown a significant reduction of cancer related mortality in subjects at high risk of lung cancer. However, high rate of false positives and overdiagnosis have led to invasive methods, which are not without risks. Evaluation of lung nodules using lung MRI with ultra short echo time sequences (UTE) has been found comparable to chest CT scans. Moreover, MRI has the advantage of multiparametric characterization of lesions using different tissue contrasts. Following the recommendation of the French National Authority for Health (HAS) to evaluate new methods of lung cancer screening, this prospective single center pilot study is designed to evaluate the performance of multiparametric lung MRI combined to synthetic CT in the diagnosis of lung cancer in heavily smokers or ex-smokers professionally exposed to carcinogens

Eligibility

Min Age: 55 YearsMax Age: 74 Years

Plain Language Summary

Simplified for easier understanding

This study is evaluating whether lung MRI combined with a computer-generated CT scan (called a synthetic CT) can be used instead of traditional CT scans to monitor people with lung conditions — reducing radiation exposure while maintaining image quality. **You may be eligible if...** - You have a lung condition requiring regular imaging follow-up (such as lung cancer, pulmonary fibrosis, or nodules) - You are scheduled for a standard CT scan as part of your care - You are able to lie still for an MRI scan - You are 18 or older **You may NOT be eligible if...** - You have a metal implant or pacemaker that prevents MRI - You have severe claustrophobia - You are unable to hold your breath for short periods - You are pregnant Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

DEVICEmultiparametric MRI

An MRI scan will be performed within 2 weeks of the discovery of a solid lung nodule ≥ 5mm on the screening scan. When a follow-up scan is indicated, an MRI will be repeated on the same day as the follow-up scan. The MRI sequences that will be performed are: SpiraleVibe UTE, T1map, T2 map and Diffusion. A synthetic scanner image will be generated from the UTE morphological MRI image using a generative artificial intelligence (GAN) model.