RecruitingNot ApplicableNCT06825403

Olfactory Training in Mild Cognitive Impairment


Sponsor

Jeffrey Motter

Enrollment

30 participants

Start Date

Aug 7, 2025

Study Type

INTERVENTIONAL

Conditions

Summary

Sense of smell tends to decline in individuals with early Alzheimer's disease, typically earlier than when other senses and thinking abilities begin to decline. Memory for new odors is particularly diminished in these individuals. Existing treatments for AD do not improve these symptoms. A targeted treatment for improving sense of smell, called 'Olfactory Training', has been used to improve sense of smell in people with various forms of smell loss, though it is not known whether it can improve smell abilities and thinking abilities in patients who are at high risk of developing Alzheimer's disease. The investigators will conduct a randomized clinical trial with patients who have mild cognitive impairment (MCI). This is an early phase of memory loss that is worse than normal aging and may precede Alzheimer's disease. Patients will be randomized to either olfactory memory training or visual memory training for 3 months, with a final follow-up visit at 6 months. This study will attempt to determine if olfactory training is a useful for improving smell abilities, thinking abilities, and everyday functioning by examining change in these outcomes over time.


Eligibility

Min Age: 55 YearsMax Age: 89 Years

Plain Language Summary

Simplified for easier understanding

This clinical trial is studying a behavioral approach called Olfactory Memory Training and a behavioral approach called Visual Memory Training for people with mild cognitive impairment. The study is currently recruiting participants at 1 location. People eligible for this study include aged 55 Years to 89 Years.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

BEHAVIORALOlfactory Memory Training

Participants will complete 48 OMT sessions at home lasting approximately 10 minutes each over 3 months.

BEHAVIORALVisual Memory Training

Participants will complete 48 VMT sessions at home lasting approximately 10 minutes each over 3 months.


Locations(1)

New York State Psychiatric Institute

New York, New York, United States

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NCT06825403


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