Clinical and Radiographic Evaluation of Allogenic Dentin Grafts for Alveolar Ridge Preservation
Clinical and Radiographic Evaluation of Allogenic Dentin Grafts for Alveolar Ridge Preservation: A Prospective Clinical Trial
Jordan University Hospital
10 participants
Jan 1, 2025
INTERVENTIONAL
Conditions
Summary
For the first time, allografts from human-extracted teeth will be prepared and evaluated in a prospective clinical trial to assess their efficacy for alveolar ridge preservation. The reconstruction and preservation of the alveolar ridge after tooth extraction are essential for future prosthetic rehabilitation. Autogenous bone grafts, while effective, are limited by donor site morbidity and insufficient graft quantity. Allogenic dentin grafts from healthy human donors present a scalable solution. This study aims to evaluate the biocompatibility and effectiveness of two types of allogenic dentin grafts-demineralized dentin allografts (DDA) and whole tooth allografts (WTA)-for alveolar ridge preservation, contributing to innovative, sustainable dental practices.
Eligibility
Inclusion Criteria7
- Students, interns, or residents willing to participate and provide informed consent.
- No history of systemic diseases such as diabetes, hepatitis, or immune disorders.
- Negative blood screening for HIV, HBV, and HCV.
- Non-smokers or individuals who have not smoked within the last six months.
- Patients aged 18-60 years, requiring extraction of at least three teeth for clinical or therapeutic reasons.
- Patients in good systemic health without conditions that impair bone healing.
- Willingness to provide informed consent and participate in follow-ups.
Exclusion Criteria14
- History of systemic conditions affecting oral or overall health.
- Positive blood tests for communicable diseases.
- Active oral infections or untreated dental caries.
- Pregnant or lactating individuals.
- Individuals with a history of smoking or substance abuse within the last six months.
- Systemic conditions such as diabetes, osteoporosis, or immunodeficiency that could impair bone regeneration.
- Active oral infections at extraction sites.
- History of radiation therapy to the head and neck region.
- Smoking or smoking history within the last six months.
- Use of medications affecting bone metabolism (e.g., bisphosphonates, steroids).
- Pregnancy or lactation. Additional Justification for Extraction: Teeth chosen for extraction must meet one or more criteria:
- Severe periodontal disease.
- Irreversible pulpitis or structural damage.
- Non-restorable condition impacting oral health or functionality.
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Interventions
: demineralized dentin allografts (DDA) allografts from human extracted teeth will be prepared and evaluated in a prospective clinical trial to assess their efficacy for alveolar ridge preservation. The reconstruction and preservation of the alveolar ridge after tooth extraction are essential for future prosthetic rehabilitation. Autogenous bone grafts, while effective, are limited by donor site morbidity and insufficient graft quantity. Allogenic dentin grafts, derived from healthy human donors, present a scalable solution.
whole tooth allografts (WTA) allografts from human extracted teeth will be prepared and evaluated in a prospective clinical trial to assess their efficacy for alveolar ridge preservation. The reconstruction and preservation of the alveolar ridge after tooth extraction are essential for future prosthetic rehabilitation. Autogenous bone grafts, while effective, are limited by donor site morbidity and insufficient graft quantity. Allogenic dentin grafts, derived from healthy human donors, present a scalable solution.
Locations(1)
View Full Details on ClinicalTrials.gov
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NCT06827665