A Study Comparing Immunotherapy Alone Versus Immunotherapy Combined With Radiotherapy in Patients With Hepatocellular Carcinoma (HCC) With Vascular Invasion

This study is comparing two treatments for liver cancer (hepatocellular carcinoma, or HCC) that has invaded blood vessels — a serious condition that makes surgery difficult. Patients will receive either immunotherapy alone or immunotherapy combined with radiation therapy, to see which approach works better. **You may be eligible if...** - You are 19 years or older - You have been diagnosed with liver cancer (HCC) confirmed by imaging or biopsy - Your cancer is unresectable or has spread, and it has invaded major blood vessels (such as the portal vein or hepatic vein) - You have not previously received systemic (whole-body) treatment for liver cancer - Your liver function is within acceptable limits **You may NOT be eligible if...** - You have previously received systemic therapy for HCC - You have other active cancers - You have severe liver dysfunction or uncontrolled liver disease - You have autoimmune conditions that would make immunotherapy unsafe - You are unable to provide informed consent Talk to your doctor to see if this trial is right for you.