Aquagenic Wrinkling Prediction
Using Aquagenic Wrinkling to Predict CF Carrier State
University of Iowa
2,000 participants
Mar 6, 2025
OBSERVATIONAL
Conditions
Summary
The goal of this observational study is to determine whether an aquagenic wrinkling procedure (i.e., soaking hands in a water bath for up to 20 minutes) can be used as a screening tool for cystic fibrosis carrier status. Participants will complete one visit where they will undergo an aquagenic wrinkling procedure to see how their hands respond.
Eligibility
Inclusion Criteria1
- Interested in participating in other CF Carrier-related research studies.
Exclusion Criteria12
- CF patient status
- Unable to speak English
- Unable to provide written informed consent
- Prisoner status
- An open wound on either hand
- A tattoo on either hand
- Missing any portion of either hand
- Diagnosis of Diabetes
- Diagnosis of Hyperhidrosis
- Diagnosis of Raynaud's Disease
- Diagnosis of Atopic Dermatitis
- Regularly taking ACE inhibitors or angiotensin receptor blockers
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Interventions
Participants will be asked to remove all jewelry from the hand(s) and wrist(s) that will be undergoing the aquagenic wrinkling procedures. Photographs will be taken of the palmar surface of the hand(s). The participant will submerge the hand(s) undergoing testing in a water bath for one minute. After one minute, they will remove their hand(s), dry them gently with a towel, and photographs will be taken of the palmar surface of the hand(s). The participant will re-submerge their hand(s) in the appropriate conditions for another minute and the process will be repeated 20 times for 20 total minutes submerged in the water.
Locations(1)
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NCT06831110