Hyperthermia With Chemoradiotherapy in Rectal Cancer

This trial is testing whether adding hyperthermia (controlled heat applied to the tumor area) to standard combined chemotherapy and radiation treatment (chemoradiotherapy) improves outcomes in patients with high-risk rectal cancer. Heating tumors can make cancer cells more vulnerable to radiation and chemotherapy. **You may be eligible if...** - You have been diagnosed with rectal cancer confirmed by biopsy, located in the lower or middle part of the rectum - Your cancer has high-risk features on MRI (such as invading nearby structures, spreading to many lymph nodes, or invading nearby blood vessels) - You have been recommended for total neoadjuvant therapy (treatment before surgery) - You are at least 18 years old - You have had appropriate staging scans (pelvic MRI and body CT) **You may NOT be eligible if...** - Your cancer does not have high-risk features - You have distant metastases (cancer spread to other organs) - You cannot undergo the required staging procedures Talk to your doctor to see if this trial is right for you.