Prescription Opioids, Brain Structure, and Cognition in Older Adults With Chronic Pain
Imaging, Cognition, and Opioids in Older Adults With Chronic Pain (I-COAP) Trial
Mayo Clinic
200 participants
Apr 16, 2025
INTERVENTIONAL
Conditions
Summary
The purpose of this study is to determine whether exposure to prescription opioids is associated with brain structural changes on magnetic resonance imaging (MRI), with the primary outcome of white matter integrity as measured by fractional anisotropy of the corpus callosum.
Eligibility
Plain Language Summary
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Interventions
Subjects will receive oral oxycodone as needed for pain which will be titrated weekly based on pain response, adverse effects, and patient preference. Subjects with intolerance to oxycodone will receive the equivalent dosing of morphine as an alternative.
Subjects will receive a placebo capsule identical to oxycodone, which will similarly be titrated weekly. Subjects with intolerance to the first placebo will receive another placebo capsule identical to morphine.
Locations(1)
View Full Details on ClinicalTrials.gov
For the most up-to-date information, visit the official listing.
NCT06837857