RecruitingNCT06840717

Association Between Genetic Polymorphisms and Type 2 Asthma in Children

Association Between Cytokines Gene Single Nucleotide Polymorphisms and Type 2 Inflammatory Asthma in Children


Sponsor

Guangzhou Institute of Respiratory Disease

Enrollment

300 participants

Start Date

Jan 30, 2024

Study Type

OBSERVATIONAL

Conditions

Summary

To further understand the role of gene single nucleotide polymorphism (SNP) in the occurrence of type 2 inflammation-related asthma in children by analyzing the gene single nucleotide polymorphism (SNP), lung function and type 2 inflammation indicators of children diagnosed with asthma in outpatient and inpatient. To provide a theoretical basis for the study of personalized treatment and prevention strategies for asthma.


Eligibility

Min Age: 3 YearsMax Age: 14 Years

Inclusion Criteria4

  • All children with asthma diagnosis accord with the GINA in 2023 edition;
  • Other diseases that could cause wheezing and cough were excluded, such as acute laryngitis, diphtheria, congenital airway abnormalities, and tracheal foreign bodies;
  • In front of the hospital 2 weeks without antibiotics, systemic hormone medication history;
  • There were no other complications, such as congenital heart disease, pneumonia, gastroesophageal reflux disease, muscle dysplasia, etc.

Exclusion Criteria3

  • Children who had taken immunosuppressants, antibiotics and other drugs for a long time before admission;
  • Children with primary immunodeficiency disease;
  • The children and their families failed to cooperate or refused the experimental observation.

Locations(1)

Guangzhou institute of respiratory disease

Guangzhou, Guangdong, China

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NCT06840717


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