RecruitingNCT06841471

Role of Corneal Nerves in Dry Eye Disease

Association Between Corneal Sensitivity, Nerve Morphology, Tear Film Homeostasis and Dry Eye Symptoms

Sponsor

Daniela Nosch

Enrollment

140 participants

Start Date

Feb 20, 2025

Study Type

OBSERVATIONAL

Conditions

Dry Eye Disease (DED)Dry Eye Dry Eye Sensation Corneal Nerve

Summary

This study aims to determine whether corneal nerve function and morphology are affected by tear film instability and ocular surface homeostasis loss. Additionally, it seeks to investigate whether these factors vary based on the severity of dry eye symptoms.

Eligibility

Min Age: 18 Years

Inclusion Criteria2

Group with DED: Diagnosis of DED based on the TFOS DEWS II report
Group without DED: No diagnosis of DED

Exclusion Criteria7

Systemic disease that may affect ocular health and innervation
injury or history of operations on the anterior or posterior segment of the eye, which can affect the corneal structure and physiology
regular application of systemic or ocular medication known to affect the tear film except from DED medications
eye drops or makeup on the day of measurement.
Remarks:
Contact lens wearers are asked not to wear contact lenses for 1 week before the first appointment.
Participant with DED medications will be asked to use only conservative-free eye drops on the days of examination