Dry Eye Clinical Trials

80 recruitingLast updated: June 18, 2026

There are 80 actively recruiting dry eye clinical trials across 24 countries. Studies span Not Applicable, Phase 4, Phase 2, Phase 3, Phase 1, Early Phase 1. Top locations include Memphis, Tennessee, United States, Newport Beach, California, United States, Singapore, Singapore. Updated daily from ClinicalTrials.gov.


Dry Eye Trials at a Glance

80 actively recruiting trials for dry eye are listed on ClinicalTrialsFinder across 6 cities in 24 countries. The largest study group is Not Applicable with 29 trials, with the heaviest enrollment activity in Memphis, Newport Beach, and Singapore. Lead sponsors running dry eye studies include Aston University, Cairo University, and Indiana University.

Treatments under study

About Dry Eye Clinical Trials

Looking for clinical trials for Dry Eye? There are currently 41 studies actively recruiting participants. Clinical trials offer access to new treatments before they are widely available, and every approved therapy in use today was first tested through a clinical trial.

Below you can browse trials, sign up for alerts when new Dry Eye trials open, and view eligibility criteria for each study. Each listing includes the study phase, locations, and enrollment details.

Frequently Asked Questions

Common questions about Dry Eye clinical trials

A clinical trial is a carefully designed research study that tests new medical treatments, drugs, devices, or approaches in human volunteers. Every approved medication and treatment available today was proven safe and effective through clinical trials.

All clinical trials are reviewed and approved by Institutional Review Boards (IRBs) — independent committees that evaluate patient safety. Trials follow strict protocols, and your health is monitored closely throughout. You can withdraw at any time.

Not necessarily. Many trials compare the new treatment against the current standard of care, meaning all participants receive active treatment. When placebos are used, they are typically combined with standard treatment, not given alone. The trial description will always specify the design.

Under the Affordable Care Act, most private insurers are required to cover routine patient care costs during a clinical trial. The sponsor typically covers the investigational treatment itself. Medicare also covers routine costs for qualifying trials.

Yes. Participation is completely voluntary. You can withdraw at any time, for any reason, without it affecting your access to standard medical care.

Each trial has specific eligibility criteria — including age, diagnosis, disease stage, prior treatments, and general health. Browse the trials listed above and check their eligibility sections. You can also contact the trial site directly to discuss your situation.

Showing 120 of 80 trials

Recruiting

Impact of GLP-1 Receptor Agonists on Dry Eye Disease in Patients With Type 2 Diabetes Mellitus and Obesity

Dry Eye Disease (DED)Diabetes Type 2Diabete Mellitus+3 more
Attikon Hospital100 enrolled1 locationNCT07605572
Recruiting
Phase 2Phase 3

A Clinical Study Evaluating Licaminlimab for Dry Eye Disease

Dry Eye Disease (DED)
Oculis160 enrolled14 locationsNCT07548632
Recruiting
Not Applicable

The Effect of Rinsing on Ocular Inflammation and Symptoms in Patients With Dry Eye Disease

Dry EyeDry Eye SyndromesOcular Surface Disease
Rinsada33 enrolled1 locationNCT07618364
Recruiting
Phase 4

Ocular Surface Health and Tear Film Stability With a Nasal Spray Dry Eye Treatment

Dry EyeMeibomian gland dysfunction
University of California, Berkeley65 enrolled1 locationNCT07606625
Recruiting
Phase 1

A Study to Assess Adverse Events, How the Drug Moves Through the Body and Effectiveness of Intravenous Infusions of ABBV-319 in Adult Participants With Systemic Lupus Erythematosus (SLE) and Sjogren's Disease (SjD)

dry eye syndromeSystemic Lupus Erythematosus
AbbVie36 enrolled7 locationsNCT06977724
Recruiting
Not Applicable

Evaluation of a Novel Ocular Lubricating Eye Drop

Dry Eye Syndrome (DES)
Pleryon Therapeutics (Hangzhou) Limited40 enrolled1 locationNCT07593404
Recruiting
Not Applicable

A Study to Evaluate the Performance and Safety of Artelac® Complete MDO® Versus VISMED® MULTI Eye Drops in the Management of Moderate to Severe Dry Eye Disease

Dry Eye
Dr. Gerhard Mann chem.-pharm. Fabrik GmbH160 enrolled5 locationsNCT07593885
Recruiting
Not Applicable

BriTer Eyez Moisture Vue™ On-Demand Disposable Moisture Chamber

Dry Eye Disease (DED)
University of Rochester35 enrolled1 locationNCT07430735
Recruiting
Not Applicable

Impact of Filtration on Autologous Serum Eye Drops

Dry Eye Syndrome (DES)
University Hospital, Limoges10 enrolled1 locationNCT07407101
Recruiting

Comparative Assessment of Lipid Layer Thickness Measurements

Dry Eye
Indiana University50 enrolled1 locationNCT07579130
Recruiting
Not Applicable

Upper Punctal Plug Occlusion in Previous Lower Punctal Occlusion.

DEDAqueous-deficient Dry Eye Disease
Universidad Autonoma de Nuevo Leon36 enrolled1 locationNCT07571330
Recruiting
Phase 4

The Effects of 3% Trehalose Ophthalmic Solution on Corneal Epithelial Barrier Function

Dry Eye Disease (DED)
Southern California College of Optometry at Marshall B. Ketchum University30 enrolled1 locationNCT06655441
Recruiting
Not Applicable

The Effect of 0.1% Topical Ciclosporin A for 12-weeks on the Eye Surface Immune Cells in Dry Eyes

Dry Eye Disease (DED)
The University of New South Wales60 enrolled1 locationNCT06898853
Recruiting

Real-World Assessment of VEVYE® for Short-Term Symptom and Sign Improvement of Dry Eye Disease in a Neuro-Ophthalmology Clinic: A 6-Month Prospective Observational Study

Dry Eye
Neuro-Ophthalmology of Texas50 enrolled1 locationNCT07566975
Recruiting

Detection and Optimization of Treatment of Severe Cases of Dry Eye Disease

Dry Eye
Singapore National Eye Centre200 enrolled1 locationNCT07554911
Recruiting
Not Applicable

Therapeutic Efficacy and Safety of Non-Invasive RF Treatment in Refractory MGD

Dry Eye SyndromesMeibomian gland dysfunction
The University of Hong Kong112 enrolled2 locationsNCT06220474
Recruiting
Phase 4

Comparison of Ocular Lubricants in People With Symptoms of Dry Eye

Dry Eye Symptoms
University of Waterloo100 enrolled1 locationNCT07451184
Recruiting

Proteomic and Metabolomic Lacrimal Fingerprint in Diverse Pathologies of the Ocular Surface

allergic conjunctivitisdry eye syndromeMucous Membrane Pemphigoid+1 more
Centre hospitalier de l'Université de Montréal (CHUM)300 enrolled2 locationsNCT04198740
Recruiting
Phase 4

Single-Arm Study of a Treatment for Dry Eye in People Who Struggle to Wear Contact Lenses

Dry Eye
Vision Innovation Centers of Pennsylvania, LLC d/b/a Eye Care Specialists30 enrolled1 locationNCT07510620
Recruiting
Phase 4

SYSTANE® PRO vs. MIEBO™ in Dry Eye Disease

Dry Eye Disease (DED)
Indiana University260 enrolled4 locationsNCT07243275