Dry Eye Clinical Trials

35 recruiting

Dry Eye Trials at a Glance

65 actively recruiting trials for dry eye are listed on ClinicalTrialsFinder across 6 cities in 20 countries. The largest study group is Not Applicable with 20 trials, with the heaviest enrollment activity in Memphis, Newport Beach, and Singapore. Lead sponsors running dry eye studies include Aston University, Medical University of Vienna, and Singapore National Eye Centre.

Treatments under study

About Dry Eye Clinical Trials

Looking for clinical trials for Dry Eye? There are currently 35 studies actively recruiting participants. Clinical trials offer access to new treatments before they are widely available, and every approved therapy in use today was first tested through a clinical trial.

Below you can browse trials, sign up for alerts when new Dry Eye trials open, and view eligibility criteria for each study. Each listing includes the study phase, locations, and enrollment details.

Frequently Asked Questions

Common questions about Dry Eye clinical trials

A clinical trial is a carefully designed research study that tests new medical treatments, drugs, devices, or approaches in human volunteers. Every approved medication and treatment available today was proven safe and effective through clinical trials.

All clinical trials are reviewed and approved by Institutional Review Boards (IRBs) — independent committees that evaluate patient safety. Trials follow strict protocols, and your health is monitored closely throughout. You can withdraw at any time.

Not necessarily. Many trials compare the new treatment against the current standard of care, meaning all participants receive active treatment. When placebos are used, they are typically combined with standard treatment, not given alone. The trial description will always specify the design.

Under the Affordable Care Act, most private insurers are required to cover routine patient care costs during a clinical trial. The sponsor typically covers the investigational treatment itself. Medicare also covers routine costs for qualifying trials.

Yes. Participation is completely voluntary. You can withdraw at any time, for any reason, without it affecting your access to standard medical care.

Each trial has specific eligibility criteria — including age, diagnosis, disease stage, prior treatments, and general health. Browse the trials listed above and check their eligibility sections. You can also contact the trial site directly to discuss your situation.

Showing 120 of 65 trials

Recruiting

Detection and Optimization of Treatment of Severe Cases of Dry Eye Disease

Dry Eye
Singapore National Eye Centre200 enrolled1 locationNCT07554911
Recruiting
Not Applicable

Therapeutic Efficacy and Safety of Non-Invasive RF Treatment in Refractory MGD

Dry Eye Syndromes
The University of Hong Kong112 enrolled2 locationsNCT06220474
Recruiting
Phase 2Phase 3

A Clinical Study Evaluating Licaminlimab for Dry Eye Disease

Dry Eye Disease (DED)
Oculis160 enrolled10 locationsNCT07548632
Recruiting
Phase 4

Comparison of Ocular Lubricants in People With Symptoms of Dry Eye

Dry Eye Symptoms
University of Waterloo100 enrolled1 locationNCT07451184
Recruiting
Phase 4

Single-Arm Study of a Treatment for Dry Eye in People Who Struggle to Wear Contact Lenses

Dry Eye
Vision Innovation Centers of Pennsylvania, LLC d/b/a Eye Care Specialists30 enrolled1 locationNCT07510620
Recruiting
Phase 4

SYSTANE® PRO vs. MIEBO™ in Dry Eye Disease

Dry Eye Disease (DED)
Indiana University260 enrolled4 locationsNCT07243275
Recruiting
Phase 4

A Non-interventional Study to Evaluate the Anti-inflammatory Effects and the Clinical Efficacy of Topical Water Free Cyclosporin 0.1% Eye Drops in Patients With Dry Eye Disease and Associated Ocular Surface Inflammation Non-responding to Artificial Tears: the FOCUS Study

Dry Eye Disease (DED)
Medical University of Vienna25 enrolled1 locationNCT07463950
Recruiting

Ocular Complications From Cancer Therapy - Patient Registry and Biobank

Ocular ComplicationsGraft Versus Host Disease in EyeInflammatory Dry Eye Disease
University of Maryland, Baltimore150 enrolled1 locationNCT06874283
Recruiting
Not Applicable

Clinical Investigation Between the Topical Administration of a Tear Substitute With Ancillary Medicinal Substance and Hyaluronic Acid 0.3% (FBV_01) vs Hyaluronic Acid 0.3% in Subjects in the Treatment From Moderate to Severe DED

Dry Eye Disease (DED)Dry Eye Syndromes
FB Vision S.p.A74 enrolled2 locationsNCT07412860
Recruiting
Phase 4

Supplementary Kelulut Honey Therapy in Juvenile Open-Angle Glaucoma: Effects on IL-6, RNFL and Dry Eye

Juvenile Open Angle GlaucomaDry Eye Disease (DED)Interleukin 6+2 more
Universiti Sains Malaysia60 enrolled4 locationsNCT07396441
Recruiting
Not Applicable

Impact of Tixel Treatment on Symptoms and Signs in Patients With Dry Eye Disease

Dry Eye Disease (DED)
Aston University36 enrolled1 locationNCT06615453
Recruiting
Not Applicable

Photobiomodulation With REd vs BluE Light (REBEL)

Dry Eye Syndromes
Aston University36 enrolled2 locationsNCT06371300
Recruiting
Not Applicable

Protecting the Eyes of Gamers With Lubricating Eyedrops

Dry Eye Syndromes
Aston University28 enrolled1 locationNCT06163989
Recruiting
Not Applicable

PCOS and Problem of Eye Dryness: Is There a Benefit From Lifetyle Changes

ObesityPolycystic Ovary SyndromeDry Eye
Cairo University40 enrolled1 locationNCT07366944
Recruiting

Comparing Tear Proteomics Profile in Dry Eye Disease pre-and Post-treatment With Low Level Light Therapy

Dry EyeMeibomian Gland Dysfunction (Disorder)
Singapore National Eye Centre30 enrolled1 locationNCT07329712
Recruiting

SAS 1: Develop Ocular Disease (OSD) Diagnostic, Algorithms, and Management Protocols for Cataract Surgery

Dry Eye
Louis Tong110 enrolled1 locationNCT07323264
Recruiting
Phase 1Phase 2

Preliminary Clinical Study of the Effectiveness and Safety of Ocular Surface Microbiota Transplantation in the Treatment of Dry Eye Disease

Dry Eye
Second Affiliated Hospital of Nanchang University40 enrolled1 locationNCT07298811
Recruiting
Not Applicable

Eyelid Closure in Keratometry

Dry EyeOcular Surface Disease
Vienna Institute for Research in Ocular Surgery29 enrolled1 locationNCT07297849
Recruiting

Three-dimensional Analysis of EMMPRIN on Conjunctival Epithelial Cells Surface in Severe Dry Eye Syndrome (ALTESSE)

Dry Eye SyndromesConjunctival Diseases
Fondation Ophtalmologique Adolphe de Rothschild100 enrolled1 locationNCT03358979
Recruiting
Not Applicable

Kelulut Honey for Allergic Conjunctivitis and Dry Eye Symptoms

Dry Eye SymptomsAllergic Conjunctivitis of Both Eyes
Universiti Sains Malaysia72 enrolled1 locationNCT07273747