RecruitingNot ApplicableNCT06845046

A Study to Improve Skeletal Muscle in Veterans With HIV

A Randomized Trial to Optimize Skeletal Muscle While Reducing Adiposity in Veterans With HIV

Sponsor

VA Office of Research and Development

Enrollment

70 participants

Start Date

Jul 15, 2025

Study Type

INTERVENTIONAL

Conditions

Obesity HIV

Summary

The Department of Veterans Affairs is the largest single provider of medical care to people with HIV in the United States. The condition of excess lipid within and around muscle, termed myosteatosis, predisposes Veterans to physical function decline, frailty, disability, and cardiometabolic diseases such as diabetes and cardiovascular disease. In the investigators current Merit supported cohort, the investigators found that 36% of Veterans with treated HIV and obesity have "myosteatotic type obesity". Based on the investigators findings, the investigators have designed a multipronged integrated intervention that combines: 1) dietary replacement of saturated with unsaturated fats; 2) administration of L-carnitine and omega-3 fatty acid supplementation; and 3) targeted resistance exercise training.

Eligibility

Sex: MALEMin Age: 20 YearsMax Age: 80 Years

Plain Language Summary

Simplified for easier understanding

This study is testing whether a specific exercise and nutrition program can improve skeletal muscle health and metabolic function in military veterans living with HIV who are overweight, particularly those taking a common class of HIV medications. **You may be eligible if...** - You are a veteran living with HIV - You have been on integrase strand transfer inhibitor (INSTI) HIV treatment for at least 3 months and your virus is undetectable - You are at least 20 years old - Your BMI is between 28 and 50 **You may NOT be eligible if...** - Your weight has changed significantly (more than 5%) in the past 3 months - You have diabetes (Type 1 or Type 2) or are on diabetes medication - You have significant kidney disease or chronic inflammation - You take supplements known to affect muscle or body composition Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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