RecruitingNot ApplicableNCT06848205

Percept Transitions in FOG and PD

Basal Ganglia Contributions to Transitions in Freezing of Gait and Parkinson's Disease

Sponsor

University of Minnesota

Enrollment

36 participants

Start Date

Feb 26, 2026

Study Type

INTERVENTIONAL

Conditions

Parkinson Disease Freezing of Gait

Summary

The purpose of this research is to examine the possible causes and signs of freezing of gait (FOG) secondary to Parkinson's disease (PD). To achieve this, the study will use the novel (on-label and FDA-approved) local field potential (LFP) measuring capability of the Medtronic Percept™ deep brain stimulation (DBS) system to compare oscillatory activity in people who have Parkinson's disease, with and without freezing of gait (FOG). This will be conducted as three separate experiments, participants may volunteer for one or more experiments: Experiment 1: The first experiment will compare LFPs during gait initiation with and without a cue, in people with (PD+FOG) and without FOG (PD-FOG). Experiment 2: The second experiment will compare LFPs during the successful movement transitions vs. freezing-events during a FOG provocation course in people with FOG. Experiment 3: The third experiment will compare LFPs during rapid alternating movements of the wrist and/or foot, in people with and without FOG

Eligibility

Min Age: 21 YearsMax Age: 75 Years

Plain Language Summary

Simplified for easier understanding

This study is investigating how perception and movement change in people with Parkinson's disease who experience 'freezing of gait' (sudden episodes where the feet feel stuck to the ground) using a specialized implanted brain stimulator device called the Medtronic Percept. **You may be eligible if...** - You have been diagnosed with idiopathic (common) Parkinson's disease - You are between 21 and 75 years old - You can walk independently for at least 50 meters without a cane or other assistive device - You already have a Medtronic Percept deep brain stimulation device implanted - You have been using the device for at least 3 months **You may NOT be eligible if...** - You require a walking aid - You do not have the Medtronic Percept device implanted - You have a different or unclear form of parkinsonism Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

OTHEROFF Parkinson's Medication(s)

Participants will be asked to withhold Parkinson's medications 12 hours prior to their testing visit (if extended-release Parkinson's medications are taken by the participant, they will be asked to withhold these for 24 hours prior to their testing visit).

OTHEROFF Deep Brain Stimulation

Participants will have their deep brain stimulation turned off at the beginning of their testing visit.