RecruitingNot ApplicableNCT06848530

Neurophysiology of the Basal Ganglia, Thalamus, and Cerebellum in Patients With Movement Disorders


Sponsor

University of Pennsylvania

Enrollment

100 participants

Start Date

Dec 10, 2025

Study Type

INTERVENTIONAL

Conditions

Summary

The research study is being conducted to better understand parts of the human brain called the cortex, basal ganglia, thalamus, and cerebellum in patients with movement disorders (such as Parkinson's disease, essential tremor, dystonia, or ataxia). These brain structures are involved in movement disorders. This study attempts to better understand the brain electrical activity associated with these disorders, both in patients with and without deep brain stimulation (DBS). Recordings are made from the scalp with a noninvasive electrode and/or through the DBS stimulator if the participant has a stimulator model that is able to sense brain activity. These recordings are analyzed along with measures of movement disorder symptoms to identify brain signal signatures of symptoms.


Eligibility

Min Age: 18 Years

Inclusion Criteria7

  • Patients 18 years of age and above
  • Any patient who has been diagnosed by a movement disorders neurologist with one of the following movement disorders:
  • Parkinson's disease
  • Dystonia
  • Tremor, including essential tremor
  • Cerebellar ataxia
  • Other hyperkinetic movement disorders, such as chorea and tics

Exclusion Criteria1

  • \- Patients with dementia

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Interventions

OTHERPrescribed Medications

participant's movement disorders medications, prescribed by their treating physician

OTHERDeep brain stimulation adjustment

Deep brain stimulator parameters may be adjusted within normal clinical limits


Locations(1)

Pennsylvania Hospital

Philadelphia, Pennsylvania, United States

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NCT06848530


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