Ketogenic Diet Prior to Bariatric Surgery
The Impact of a Preoperative Very Low Calorie Ketogenic Diet (VLCKD) on Body Composition in Patients Undergoing Bariatric Surgery: a Randomised Controlled Trial
Maxima Medical Center
46 participants
Sep 1, 2022
INTERVENTIONAL
Conditions
Summary
Standard dietary regiments for bariatric are advised prior to surgery. The most used diet is a very low calorie diet (VLCD). These diets potentially have multiple pittfalls. Very low-calorie ketogenic diets (VLCKD) have been proposed as a new regimen for achieving weight- and liver volume loss in patients undergoing bariatric surgery. The beneficial effect of VLCKDs compared to (V)LCDs is the aimed preservation of FFM and RMR, while still reducing FM. Only a few small studies addressed the role of VLCKDs prior to bariatric surgery, and the data including FFM and FM is actually scarce. Therefore, a well-designed randomised controlled trial is necessary to establish the efficacy of a VLCKD.
Eligibility
Inclusion Criteria3
- Eligible for bariatric surgery (≥35 kg/m2 with obesity-related comorbidities, or a BMI of
- kg/m2 with or without comorbidities)
- Roux-en-Y Gastric bypass (RYGB)
Exclusion Criteria11
- Weighing over 150kg because this amount is a limitation by the DXA device
- Diabetes mellitus type 1
- Allergic to milk proteins
- A recent history of a heart attack (< 12 months), heart failure or cardiac arrhythmias
- Kidney and/or liver failure (creatinine levels >1.3 mg/dl or liver enzyme levels (AST, ALT, GGT)) less than three times over the upper normal threshold
- Current infectious, sepsis or malignant disease
- Rare condition like galactosemia, phenylketonuria or porphyria
- Persistent diarrhoea
- Hypokalaemia, chronic therapies with diuretics as furosemide and hydrochlorothiazide
- Pregnancy or plans to get pregnant in the coming months
- Patients who did not meet criteria to be eligible for bariatric surgery (BMI <35, psychological or unstable psychiatric disorders, inadequate dietary regimen or inadequate exercise pattern which can't be resolved in the upcoming 6 months)
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Interventions
diets prior to bariatric surgery
diets prior to bariatric surgery
Locations(1)
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NCT06850493