A Study to Evaluate the Safety, Tolerability, Pharmacokinetics, and Efficacy of RO7446603 Administered Alone or in Combination With Aflibercept or Faricimab in Participants With Diabetic Macular Edema
A Phase I/II Study to Evaluate the Safety, Tolerability, Pharmacokinetics, and Efficacy of RO7446603 Administered Alone or in Combination With Aflibercept or Faricimab in Patients With Diabetic Macular Edema
Genentech, Inc.
546 participants
Jun 22, 2022
INTERVENTIONAL
Conditions
Summary
This study aims to evaluate the ocular and systemic safety, tolerability and efficacy of RO7446603 in participants with diabetic macular edema (DME). The study consists of 2 segments: Phase I (Parts 1-4) and Phase II (Part 5). Phase I investigated the safety of RO7446603 following a single and multiple intravitreal (IVT) doses as monotherapy or co-administered with IVT aflibercept or IVT faricimab (in separate injections). Phase II will investigate the safety, tolerability, pharmacokinetics (PK) and efficacy of two dose levels of RO7446603 in combination with faricimab, with the two drugs co-mixed and administered as a single IVT injection, compared to faricimab alone. The first participant was enrolled in the Phase I segment on June 22, 2022. Phase I has been completed.
Eligibility
Inclusion Criteria3
- Documented diagnosis of diabetes mellitus (DM) (Type 1 or Type 2) with glycated hemoglobin (HbA1c) \< 12%
- Macular thickening secondary to DME involving the center of the fovea \> 325 microns
- Decreased VA attributable primarily to DME between 25 and 73 ETDRS letters
Exclusion Criteria8
- Currently untreated DM or previously untreated participants who initiated oral anti-diabetic medication or insulin within 90 days prior to Day 1
- Uncontrolled blood pressure (BP)
- Pregnancy or breastfeeding, or intention to become pregnant during the study
- For Parts 1-4: IVT anti-VEGF treatment within 90 days prior to Day 1; For Part 5: IVT anti-VEGF treatment within 120 days prior to Day 1 or IVT anti-VEGF treatment prior to Day 1 for treatment naïve participants
- Treatment with SUSVIMOTM (ranibizumab injection) prior to Day 1
- Any IVT or periocular (sub-tenons) corticosteroid treatment within 6 months prior to Day 1
- Any current or history of ocular disease other than DME that may confound assessment of the macula or affect central vision
- Proliferative diabetic retinopathy (PDR) in the study eye
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Interventions
Participants will receive RO7446603 as an IVT injection per the schedule described in the treatment arms.
Participants will receive aflibercept as an IVT injection per the schedule described in the treatment arm.
Participants will receive faricimab as an IVT injection per the schedule described in the treatment arms.
Locations(78)
View Full Details on ClinicalTrials.gov
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NCT06850922