Safety of Short-course of NSAIDs in Pediatric Patients With CKD

This study is looking at whether short-term use of anti-inflammatory pain medicines (like ibuprofen, called NSAIDs) is safe for children who have mild-to-moderate chronic kidney disease (CKD) and are recovering from surgery. **You may be eligible if...** - Your child is over 18 months of age - Your child has been diagnosed with CKD stages 2 or 3a, confirmed by a lab test called cystatin C in the past 6 months **You may NOT be eligible if...** - Your child has CKD stage 1 or stages 4–5 - Your child takes certain blood pressure medicines (ACE inhibitors or ARBs), diuretics, or trimethoprim - Your child received IV contrast dye in the past 30 days - Your child has a history of kidney transplant, diabetes, high blood pressure, asthma, or thyroid problems - Your child has had high potassium levels, recent steroid use, an active infection, or an allergy to NSAIDs - Surgery is being done for cancer-related reasons Talk to your doctor to see if this trial is right for you.