Roflumilast as an Adjunct to Antidepressants in Major Depressive Disorder Patients

This study is testing whether adding a drug called Roflumilast (typically used for lung disease) to standard antidepressant treatment can improve outcomes for people with major depressive disorder. **You may be eligible if...** - You are over 18 years old - You have been diagnosed with major depressive disorder and have a moderate-to-severe depression score on a clinical rating scale **You may NOT be eligible if...** - You have bipolar disorder, an eating disorder, a personality disorder, or a current anxiety disorder diagnosis (other than specific phobia) - You have had substance dependence or abuse in the last 3 months - You are pregnant or not using reliable contraception - You are currently receiving electroconvulsive therapy (ECT) - You have a condition or medical history that would make the study medication unsafe Talk to your doctor to see if this trial is right for you.