RecruitingNCT06861686

A Modified Baveno Classification of Obstructive Sleep Apnoea Based on Sleepiness and Cardiovascular Scores

A Modified Baveno Classification of Obstructive Sleep Apnoea Based on Sleepiness and Cardiovascular Scores: A Prospective Observational Cohort Study


Sponsor

Wissenschaftliches Institut Bethanien e.V

Enrollment

1,800 participants

Start Date

Mar 24, 2025

Study Type

OBSERVATIONAL

Conditions

Summary

The goal of this observational study is to evaluate a new classification system for obstructive sleep apnoea in patients with newly diagnosed obstructive sleep apnoea and monitor for long-term objective and subjective improvement.


Eligibility

Min Age: 40 Years

Inclusion Criteria3

  • Adult patient ≥40 years at the time of signed informed consent
  • Diagnosis of predominant obstructive sleep apnoea with a total apnoea-hypopnoea index of ≥5 /h based on a diagnostic sleep study (polysomnography or polygraphy, as per local standard). Predominant obstructive sleep apnoea defined as ≥70% of respiratory events classified as obstructive.
  • Signed and dated written informed consent in accordance with ICH-GCP and applicable local regulations

Exclusion Criteria6

  • >30% central respiratory events (apnoeas and hypopnoeas) within the diagnostic sleep study
  • Established sleep apnoea treatment within the last 12 months before study inclusion (positive airway pressure, mandibular advancement device, positional therapy)
  • Use, or need for chronic use, of any non-invasive positive pressure ventilation device
  • Participation in an interventional study and/or receiving investigational treatment(s)
  • Significant disease or condition, which, in the opinion of the investigator, may interfere with study procedures or cause concern regarding the patient's ability to participate in the study
  • Patients not expected to comply with the protocol requirements or not expected to complete the trial as scheduled (e.g. chronic alcohol or drug abuse or any other condition that, in the investigator's opinion, makes the patient an unreliable trial participant)

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Locations(18)

Antwerp University Hospital

Antwerp, Antwerp, Belgium

UZ Leuven

Leuven, Vlaams-Brabant, Belgium

Centre Hospitalier Universitaire Grenoble Alpes

Grenoble, Isère, France

Wissenschaftliches Institut Bethanien für Pneumologie e.V.

Solingen, Germany

Department of Pulmonology, University General Hospital of Alexandroupolis, Medical School, Democritus University of Thrace

Alexandroupoli, Evros, Greece

Division of Pulmonology, Department of Clinical Therapeutics, National and Kapodistrian University of Athens, Medical School

Athens, Greece

University of Crete

Heraklion, Greece

Respiratory Failure Unit, G. Papanikolaou Hospital

Thessaloniki, Greece

Istituto Auxologico Italiano

Milan, Italy

Istituti Clinici Scientifici Maugeri IRCCS

Pavia, Italy

Institute of Tuberculosis and Lung Diseases

Warsaw, Masovian Voivodeship, Poland

Unidade Local de Saúde de Gaia e Espinho ULSGE - Unidade de Patologia do Sons

Vila Nova de Gaia, Porto District, Portugal

Hospital Beatriz Ângelo, Unidade Local de Saúde Loures-Odivelas

Loures, Portugal

Clinica Somnolog

Bucharest, Romania

University of Medicine and Pharmacy Dr. Victor Babes

Timișoara, Romania

University Clinic of Respiratory and Allergic Diseases Golnik

Golnik, Slovenia

Klinik für Pneumologie Universitätsspital Zürich

Zurich, Switzerland

Ege University, Faculty of Medicine, Department of Respiratory Medicine

Izmir, Turkey (Türkiye)

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NCT06861686


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