RecruitingNCT06862843

Study on Eating Habits and Association with "omic" Profiles in Families with a Subject Affected by a Chronic Immune-mediated Inflammatory Pathology. Observational Multicenter Study.

Sponsor

Meyer Children's Hospital IRCCS

Enrollment

90 participants

Start Date

Feb 7, 2024

Study Type

OBSERVATIONAL

Conditions

Ulcerative Colitis (UC)Crohn Disease (CD)Juvenile Idiopathic Arthritis (JIA)

Summary

The proposed study is part of a PNRR 2022 project (call "Non-Communicable Chronic Diseases (NCDs) with high impact on healthcare and social assistance systems," currently awaiting funding response) and represents the continuation of an observational clinical study named TRANSMIC, approved by the pediatric ethics committee of the Tuscany region. TRANSMIC was an integral part of a European research project within the joint programming initiative (JPI), under the HDHL-INTIMIC theme: "A Healthy Diet for a Healthy Life," aimed at understanding the cause-effect relationships between diet, gut microbiome, and human health. Understanding the role of diet in inflammatory bowel diseases (IBD) and exploring its role in autoimmune inflammatory conditions with joint manifestations, such as JIA, provides additional insights into the development, progression, and management of these conditions, opening new horizons for the use of dietary treatments in preventing these inflammatory conditions.

Eligibility

Plain Language Summary

Simplified for easier understanding

This study is examining the eating habits and biological profiles (genetics, gut bacteria, proteins, etc.) of families where one or more members have an inflammatory bowel disease (IBD) like Crohn's disease or ulcerative colitis, or juvenile idiopathic arthritis (JIA), to understand how diet and biology interact in these conditions. **You may be eligible if...** - You are a family (parents and children aged 0–18) where at least one child or adult has IBD or a child has JIA - OR you are a healthy family with no history of chronic inflammatory conditions, serving as a comparison group **You may NOT be eligible if...** - Your child with IBD has a monogenic (single gene) disease, has had an ileostomy, or has had their colon removed - You are a healthy family but have a chronic inflammatory or autoimmune bowel disease Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

OTHERCollecting questionnaires and biological samples

For each family member will be collected a 3-days food diary, a food frequencies questionnaire and a questionnaire assessing the adherence to the mediterranean diet. Additionally, a blood sample for trascriptomic analysis and a fecal sample for gut microbiota analysis will be collected