RecruitingNCT06864156

Evaluation of MicroRNAs and Vitamin B12 Expression in Subjects with Neurologic Symptoms of Depression, Anxiety and Fatigue in Long COVID-19


Sponsor

Instituto Nacional de Rehabilitacion

Enrollment

20 participants

Start Date

Feb 18, 2025

Study Type

OBSERVATIONAL

Conditions

Summary

At the moment, the number of people with long COVID is unkown because there is still no effective diagnosis. This is why is very important to analyze the most common symptoms, which are: depression, anxiety and fatigue. This project seeks to analyze some blood components of people with long COVID, such as microRNAs and vitamin B12, in order to identify the body processes that changed after COVID-19 and thereby design better therapies and diagnostic methods focused on each of them. The hypothesis is that the expression of miR-21, -146a and -155 will be overexpressed as well as there will be a deficiency of vitamin B12 in serum in subjects suffering from long COVID with neurological symptoms of depression, anxiety and fatigue.


Eligibility

Min Age: 18 YearsMax Age: 65 Years

Plain Language Summary

Simplified for easier understanding

This study is investigating whether small molecules in the blood called microRNAs and vitamin B12 levels are different in people experiencing depression, anxiety, or fatigue as part of long COVID — symptoms that persist more than 3 months after a COVID-19 infection. **You may be eligible if...** - You have a confirmed previous COVID-19 diagnosis (by PCR or antigen test) - You are experiencing neurological symptoms of depression, anxiety, or fatigue that started after COVID-19 and have persisted for at least 3 months - You have received at least 2 doses of a COVID-19 vaccine, with the last dose given 3 or more months ago **You may NOT be eligible if...** - You are still in the acute phase of COVID-19 infection (within the last 12 weeks) - You had depression, anxiety, or neurological problems before getting COVID-19 - You have not received at least 2 COVID-19 vaccine doses Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Locations(1)

Instituto Nacional de Rehabilitación

Mexico City, Mexico City, Mexico

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NCT06864156


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