RecruitingNCT06868888

Rheological Functions of Erythrocyte in ESRD

The Effect of Osmotic Stress in Erythrocyte Rheology in ESRD Patients

Sponsor

Chang Gung Memorial Hospital

Enrollment

40 participants

Start Date

Aug 24, 2022

Study Type

OBSERVATIONAL

Conditions

End Stage Renal Disease (ESRD)

Summary

End-stage renal disease (ESRD) disrupts erythrocyte deformability due to osmotic imbalances, oxidative stress, and uremic toxins, leading to impaired microcirculation and oxygen transport. Dysregulation of ion channels, particularly the Gardos channel, exacerbates dehydration and eryptosis, further compromising vascular integrity. Given the critical role of erythrocyte flexibility in oxygen delivery, this study investigates its relationship with aerobic capacity in ESRD patients, highlighting potential mechanisms of microvascular dysfunction

Eligibility

Min Age: 20 Years

Plain Language Summary

Simplified for easier understanding

This study is looking at how red blood cells function in people with end-stage kidney disease (ESRD) who are on hemodialysis — a treatment where a machine filters your blood because your kidneys can no longer do so. **You may be eligible if...** - You are 20 years old or older - You are currently receiving hemodialysis treatment and have been for at least 6 weeks - Your dialysis is working well (measured by a score called Kt/V above 1.2) **You may NOT be eligible if...** - You are under 20 years old - You have had dangerously high potassium levels (hyperkalemia) in the past 3 months - You have bone or muscle diseases - You are pregnant - You have other medical or psychological conditions that would make participation unsafe - You have conditions that prevent you from exercising Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

OTHERBlood collection

Erythrocyte osmotic deformability was evaluated via osmotic gradient ektacytometry.

OTHERCardiopulmonary exercise testing (CPET)

Cardiopulmonary Exercise Testing (CPET) is a non-invasive assessment that evaluates the integrated function of the cardiovascular, pulmonary, and muscular systems during exercise.