Rheological Functions of Erythrocyte in ESRD
The Effect of Osmotic Stress in Erythrocyte Rheology in ESRD Patients
Chang Gung Memorial Hospital
40 participants
Aug 24, 2022
OBSERVATIONAL
Conditions
Summary
End-stage renal disease (ESRD) disrupts erythrocyte deformability due to osmotic imbalances, oxidative stress, and uremic toxins, leading to impaired microcirculation and oxygen transport. Dysregulation of ion channels, particularly the Gardos channel, exacerbates dehydration and eryptosis, further compromising vascular integrity. Given the critical role of erythrocyte flexibility in oxygen delivery, this study investigates its relationship with aerobic capacity in ESRD patients, highlighting potential mechanisms of microvascular dysfunction
Eligibility
Inclusion Criteria2
- Receiving hemodialysis and medication at least for 6 weeks
- Kt/V score \> 1.2
Exclusion Criteria6
- Under 20 years-old
- Hyperkalemia occurs within 3 month
- Having orthopedic or muscular diseases
- Other concerned medical, psychological or physiological diseases
- Pregnancy
- Other exercise contraindications
Interventions
Erythrocyte osmotic deformability was evaluated via osmotic gradient ektacytometry.
Cardiopulmonary Exercise Testing (CPET) is a non-invasive assessment that evaluates the integrated function of the cardiovascular, pulmonary, and muscular systems during exercise.
Locations(1)
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NCT06868888