RecruitingNot ApplicableNCT06869096

Chlorhexidine Gluconate Versus Saline for Flushing the Surgical Area During Colorectal Cancer Surgery

A Comparative Study of Chlorhexidine Versus Saline Irrigation of the Surgical Area During Colorectal Cancer Surgery: a Multicenter, Stratified Randomized Controlled Trial.

Sponsor

Nanchong Central Hospital

Enrollment

532 participants

Start Date

Jul 2, 2024

Study Type

INTERVENTIONAL

Conditions

Colorectal, Cancer Complications Surgical Site Infection Chlorhexidine

Summary

The aim of this study was to compare the effectiveness of chlorhexidine versus saline in flushing the surgical area during colorectal cancer surgery. The primary outcomes included surgical site infection, postoperative complication rates, et al.

Eligibility

Min Age: 18 YearsMax Age: 85 Years

Inclusion Criteria4

Patients aged 18-85 years,
Patients with surgically resectable colorectal tumors confirmed by CT/MRI before surgery
All patients had a performance status score of 0 or 1 in the Eastern Tumor Cooperative group
American Society of Anesthesiology grade I-III

Exclusion Criteria5

The tumor may have distant metastasis
History of previous abdominal surgery
The patient has a history of other malignant tumors diagnosed in the past 5 years and has received radiotherapy and chemotherapy in the past
There are obvious contraindications to surgery (obvious abnormal liver and kidney function, pregnancy)
Participated in other clinical trials within the past 6 months

Interventions

PROCEDUREIntraoperative area irrigation

After colorectal cancer surgery, flush the surgical area with chlorhexidine solution 1 minute before suturing the skin. According to abdominal cavity contamination, bleeding and tumor invasion to determine the flushing time and flush fluid volume. If the abdominal cavity infection is more serious or exudate more, the flushing time can be relatively prolonged. At last, there were no obvious blood residue, tissue fragments and suppurative secretions in abdominal cavity. Ensure that the surgical field of vision is clear, the surface of each organ is smooth, and there is no abnormal exudate.