Surgical Site Infection Clinical Trials

45 recruitingLast updated: June 18, 2026

There are 45 actively recruiting surgical site infection clinical trials across 29 countries. Studies span Not Applicable, Phase 3, Phase 4, Early Phase 1, Phase 2. Top locations include Halifax, Nova Scotia, Canada, Melbourne, Victoria, Australia, Chapel Hill, North Carolina, United States. Updated daily from ClinicalTrials.gov.


Surgical Site Infection Trials at a Glance

45 actively recruiting trials for surgical site infection are listed on ClinicalTrialsFinder across 6 cities in 29 countries. The largest study group is Not Applicable with 27 trials, with the heaviest enrollment activity in Halifax, Melbourne, and Chapel Hill. Lead sponsors running surgical site infection studies include Hospital de Granollers, Monash University, and Ondine Biomedical Inc..

Browse surgical site infection trials by phase

Treatments under study

About Surgical Site Infection Clinical Trials

Looking for clinical trials for Surgical Site Infection? There are currently 36 studies actively recruiting participants. Clinical trials offer access to new treatments before they are widely available, and every approved therapy in use today was first tested through a clinical trial.

Below you can browse trials, sign up for alerts when new Surgical Site Infection trials open, and view eligibility criteria for each study. Each listing includes the study phase, locations, and enrollment details.

Frequently Asked Questions

Common questions about Surgical Site Infection clinical trials

A clinical trial is a carefully designed research study that tests new medical treatments, drugs, devices, or approaches in human volunteers. Every approved medication and treatment available today was proven safe and effective through clinical trials.

All clinical trials are reviewed and approved by Institutional Review Boards (IRBs) — independent committees that evaluate patient safety. Trials follow strict protocols, and your health is monitored closely throughout. You can withdraw at any time.

Not necessarily. Many trials compare the new treatment against the current standard of care, meaning all participants receive active treatment. When placebos are used, they are typically combined with standard treatment, not given alone. The trial description will always specify the design.

Under the Affordable Care Act, most private insurers are required to cover routine patient care costs during a clinical trial. The sponsor typically covers the investigational treatment itself. Medicare also covers routine costs for qualifying trials.

Yes. Participation is completely voluntary. You can withdraw at any time, for any reason, without it affecting your access to standard medical care.

Each trial has specific eligibility criteria — including age, diagnosis, disease stage, prior treatments, and general health. Browse the trials listed above and check their eligibility sections. You can also contact the trial site directly to discuss your situation.

Showing 120 of 45 trials

Recruiting
Not Applicable

Subcutaneous Suture Versus no Subcutaneous Suture for Abdominal Wound Closure

Surgical Site Infection (SSI)Wound Healing Complication
University Hospital Augsburg655 enrolled1 locationNCT07615517
Recruiting
Phase 3

Evaluation of a New Strategy for Protocolized Antibiotic Care for Severe Open Fractures: SEXTANT

Post Operative Surgical Site Infection
Major Extremity Trauma Research Consortium1,200 enrolled31 locationsNCT04678154
Recruiting
Not Applicable

The Spotlight Study: Early Identification of Post-Surgical Infections Using Bedside Ultrasound.

Point of Care Ultrasound (POCUS)Surgical Site Infection (SSI)Emergency Laparotomies
Slagelse Hospital100 enrolled3 locationsNCT07549880
Recruiting
Phase 4

PeRiOperative Medicine Platform Trial

Quality of LifeAnaesthesiaSurgical Site Infection After Major Surgery+2 more
Monash University7,800 enrolled2 locationsNCT07186634
Recruiting
Not Applicable

Chlorhexidine Gluconate Versus Saline for Flushing the Surgical Area During Colorectal Cancer Surgery

Colorectal, CancerComplicationsSurgical Site Infection+1 more
Nanchong Central Hospital532 enrolled1 locationNCT06869096
Recruiting
Not Applicable

Skin Adhesive Plus Intra-cuticular Suture Versus Suture Alone for Cesarean Skin Closure

Surgical Site Infection (SSI)
Doron Kabiri240 enrolled1 locationNCT07483411
Recruiting
Not Applicable

Investigating the Impact of Cold Atmospheric Plasma Treatment on Wound Healing at Cannulation Sites in Patients Following Extracorporeal Life Support

Surgical Site InfectionWound InfectionDelayed Wound Healing+2 more
National Taiwan University Hospital65 enrolled1 locationNCT07501897
Recruiting
Phase 4

Duration of Cardiac Antimicrobial Prophylaxis Outcomes Study

Surgical Site Infection
Monash University9,180 enrolled27 locationsNCT05447559
Recruiting
Phase 4

Antibiotics for Prevention of Infection Following Orthognathic Surgery

Orthognathic Surgical Site Infection
Abdul El-Rabbany400 enrolled1 locationNCT05852158
Recruiting
Phase 4

Preoperative Clindamycin Vaginal Cream Versus Vaginal Cleansing With Povidone-iodine on Postoperative Infections After Cesarean Section

Infection Control / MethodsSurgical Site Infection (SSI)
Beni-Suef University150 enrolled1 locationNCT07474194
Recruiting

Novosyn® CHD vs Polyglactin 910 Suture to Close Wounds After Emergency or Elective Laparotomy or Laparoscopic Surgery

Surgical Site Infection
Aesculap AG2,998 enrolled4 locationsNCT05966961
Recruiting
Phase 3

Light-Activated Antimicrobial Therapy to Prevent Surgical Site Infections

Surgical Site Infections
Ondine Biomedical Inc.4,514 enrolled14 locationsNCT06702878
Recruiting
Not Applicable

Light-Activated Antimicrobial Therapy to Prevent Surgical Site Infections - Canada

InfectionsSurgical Site InfectionsSurgical Wound Infections+1 more
Ondine Biomedical Inc.4,740 enrolled4 locationsNCT07189858
Recruiting
Not Applicable

Effectiveness of Digital Game-Based Learning in Teaching Surgical Site Infection Prevention to Nursing Students

Nursing EducationSurgical Site Infection Prevention
hatice akaltun88 enrolled1 locationNCT07423702
Recruiting
Not Applicable

Studying How Outpatient Water affEcts Risks With Drains (SHOWER Study)

Postoperative wound infectionPostoperative ComplicationsSurgical Site Infection+1 more
Sean Devitt100 enrolled1 locationNCT04725916
Recruiting
Not Applicable

Prevention of Edema After Coronary Artery Bypass Graft by Customized Pressure-guided Elastic Bandages

Post-operative complicationsCABGCoronary Artery Bypass Graft+8 more
Siriraj Hospital106 enrolled2 locationsNCT06603961
Recruiting
Not Applicable

Incidence of Depression and Its Complications After Surgical Site Infection - ISODEP.

DepressionMalnutritionSurgical Site Infections
University Hospital, Bordeaux300 enrolled1 locationNCT07125196
Recruiting
Not Applicable

A Clinical Prediction Model for Surgical Site Infection After Central Nervous System Tumor Surgery

Central Nervous System TumorSurgical Site Infection (SSI)
Ming Yang500 enrolled1 locationNCT07378683
Recruiting

Effectiveness of Screening and Decolonization of S. Aureus to Prevent S. Aureus Surgical Site Infections in Surgery Outpatients

Healthcare associated infectionsSurgical Site InfectionsStaphylococcus Aureus Colonization
University of Minnesota250 enrolled1 locationNCT06378359
Recruiting
Not Applicable

Prevention of Surgical Site Infection in Open Paediatric Groin Surgeries Using Intravenous Prophylactic Antibiotics and Antimicrobial-coated Sutures

Surgical Site InfectionInguinal HerniaHydroceles
Olawumi Olajide174 enrolled1 locationNCT07346742