RecruitingNot ApplicableNCT06870110

Brain Training for Substance Use Disorders

Sponsor

Neurotype Inc.

Enrollment

40 participants

Start Date

Jan 17, 2025

Study Type

INTERVENTIONAL

Conditions

Opioid-use Disorder

Summary

Participants play games designed to train visual attention towards natural, non-drug-related scenarios. A biofeedback loop between gameplay and an electroencephalogram (EEG) system monitors game performance and guides game difficulty.

Eligibility

Min Age: 18 YearsMax Age: 65 Years

Inclusion Criteria11

OUD patient participants:
Admitted into chemical treatment with opioid use being a reason for treatment;
DSM-IV-TR diagnosis of OUD;
Ability to provide informed consent;
A minimum of a 6th grade reading level; and
Able and willing to provide own contact information for follow-up visit(s).
Control participants:
Age- and gender-matched to an OUD patient participant in the study;
Ability to provide informed consent;
A minimum of a 6th grade reading level;
Able and willing to provide own contact information for follow-up visit(s).

Exclusion Criteria14

OUD patient participants:
Refusal or inability to consent;
Pregnant;
History of serious neurological illness (e.g., Chronic seizure disorder, Wernicke-Korsakoff Syndrome, Epilepsy, Any history of seizures not caused by withdrawal from substances, Other \[please specify\]);
Inability to see text and photos clearly on the computer display; and
Unwillingness to change hairstyle (e.g., braids, pony tails, dreadlocks) or remove wig to accommodate application of the EEG headset, if necessary.
Control participants:
Refusal or inability to consent;
Pregnant;
History of serious neurological illness (e.g., Chronic seizure disorder, Wernicke-Korsakoff Syndrome, Epilepsy, Any history of seizures, Other \[please specify\]);
Inability to see text and photos clearly on the computer display;
Current or previous problems using opioids, other prescription (prescribed or not prescribed) or illicit drugs;
Regular nicotine user (e.g., cigarette smoker, e-cig user) within the past 12 months; and
Unwillingness to change hairstyle (e.g., braids, pony tails, dreadlocks) or remove wig to accommodate application of the EEG headset, if necessary.

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Interventions

DEVICEBias Modification Biofeedback

The device uses EEG-based bias modification biofeedback intended to reduce attention to drug-related cues and increase attention to non-drug pleasant scenes. Specifically, the device measures perceptual biases from Event-Related Potential biomarkers related to Substance Use Disorders.