RecruitingPhase 1NCT06873659

SON-DP in Participants With Relapsed/Refractory Intolerant to Standard of Care Therapies for Advanced/Metastatic Solid Tumors

A Phase I Dose Escalation and Expansion Study to Evaluate the Safety, Tolerability, Efficacy, Pharmacokinetics, and Pharmacodynamics of SON-DP in Subjects With Advanced Solid Tumors


Sponsor

Qurgen Inc.

Enrollment

96 participants

Start Date

Feb 26, 2025

Study Type

INTERVENTIONAL

Conditions

Summary

A Phase I Dose Escalation and Expansion Study to Evaluate the Safety, Tolerability, Efficacy, Pharmacokinetics, and Pharmacodynamics of SON-DP in Subjects with Advanced Solid Tumors


Eligibility

Min Age: 18 YearsMax Age: 75 Years

Plain Language Summary

Simplified for easier understanding

This study is testing a new experimental drug called SON-DP in people with advanced solid tumor cancers — particularly liver cancer or gastric (stomach) cancer — that have stopped responding to all available standard treatments. **You may be eligible if...** - You are between 18 and 75 years old - You have a confirmed solid tumor cancer; for the expansion phase, either advanced primary liver cancer or advanced gastric/gastroesophageal junction cancer - Your cancer has at least one measurable tumor on scans - You are in good health (ECOG performance status 0 or 1) - You are willing to have a central venous line (a special IV line) placed - Your expected survival is more than 3 months **You may NOT be eligible if...** - You are not willing to consent or cannot follow study requirements - You have already exhausted all of the listed requirements for tumor type and performance status - You do not have at least one measurable lesion visible on imaging Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

DRUGSON-DP

Solution for IV administration


Locations(11)

Cancer Hospital Chinese Academy of Medical Sciences

Beijing, Beijing Municipality, China

Beijing Cancer Hospital

Beijing, Beijing Municipality, China

Beijing GoBroad Hospital

Beijing, Beijing Municipality, China

The First Hospital of Lanzhou University

Lanzhou, Gansu, China

Sun Yat-sen University Cancer Center

Guangzhou, Guangdong, China

Sun Yat-sen University Cancer Center

Guangzhou, Guangdong, China

Jiangsu Province Hospital

Nanjing, Jiangsu, China

The First Affiliated Hospital of Xi 'an Jiaotong University

Xi'an, Shaanxi, China

Introduction to Cancer Hospital of Shandong First Medical University (Shandong Cancer Institute,Shandong Cancer Hospital)

Jinan, Shandong, China

ZhongShan Hospital Fudan University

Shanghai, Shanghai Municipality, China

Zhejiang Cancer Hospital

Hangzhou, Zhejiang, China

View Full Details on ClinicalTrials.gov

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NCT06873659


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